STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0460Similar to Streptomyces coelicolor putative ABC transporter ATP-binding subunit 2SC6G5.39c TR:Q9K4B6 (EMBL:AL359152) (346 aa) fasta scores: E(): 9.6e-39, 44.02% id in 318 aa. (324 aa)    
Predicted Functional Partners:
cstS
Histidine kinase; Almost identical to already sequenced Corynebacterium diphtheriae histidine kinase CstS TR:Q9RPE8 (EMBL:AF161328) (408 aa) fasta scores: E(): 2e-149, 97.3% id in 408 aa.
 
    0.758
DIP0461
Low similarity to Streptomyces coelicolor putative integral membrane protein SCBAC17A6.12c TR:CAC44657 (EMBL:AL596248) (387 aa) fasta scores: E(): 0.021, 30.04% id in 213 aa.
       0.735
cstA
Response regulator; Identical to previously sequenced Corynebacterium diphtheriae response regulator CstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 4.9e-83, 99.57% id in 233 aa.
       0.714
DIP0462
Putative membrane protein; No significant database matches.
       0.672
DIP0463
Putative membrane protein; Similar to Streptococcus pyogenes hypothetical protein SPY0576 TR:Q9A0X1 (EMBL:AE006514) (300 aa) fasta scores: E(): 2.3e-31, 36.93% id in 287 aa.
       0.672
DIP2143
Putative ABC transport system integral membrane protein; Weakly similar to Bacillus subtilis hypothetical YxlG TR:P94375 (EMBL:D83026) (259 aa) fasta scores: E(): 1.2, 24.72% id in 182 aa, and to Rhizobium loti Mll2378 protein TR:Q98IJ2 (EMBL:AP002999) (339 aa) fasta scores: E(): 1.3, 26.98% id in 252 aa. Lies alongside a putative ABC transporter ATP-binding subunit.
  
 
 0.589
DIP0457
Hypothetical protein; No significant database matches.
       0.458
DIP2158
Pseudogene. Similar to C-terminus of Bacteriophage SP02 DNA polymerase L SWALL:DPOL_BPSP2 (SWALL:P06225) (648 aa) fasta scores: E(): 1.3e-34, 50.61% id in 245 aa, and to Xylella fastidiosa phage-related DNA polymerase XF0683 SWALL:Q9PFH5 (EMBL:AE003912) (726 aa) fasta scores: E(): 6e-19, 32.49% id in 277 aa. Presents a frameshift at residue 46.
  
  0.430
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.