STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdaCSimilar to Escherichia coli serine transporter SdaC or DcrA or B2796 or Z4113 or ECS3656 SW:SDAC_ECOLI (P36559) (429 aa) fasta scores: E(): 4.6e-100, 61.66% id in 420 aa. (447 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
    
  0.878
sdaA
L-serine dehydratase 1; Similar to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SW:SDHL_ECOLI (P16095) (454 aa) fasta scores: E(): 4.8e-113, 63.08% id in 447 aa; Belongs to the iron-sulfur dependent L-serine dehydratase family.
 
  
 0.837
dcuA
Similar to Escherichia coli anaerobic C4-dicarboxylate transporter DcuA or GenA or B4138 or Z5743 or ECS5119 SWALL:DCUA_ECOLI (SWALL:P04539) (433 aa) fasta scores: E(): 3.1e-92, 57.33% id in 436 aa, and to Vibrio cholerae C4-dicarboxylate transporter, anaerobic VC2699 SWALL:Q9KNN2 (EMBL:AE004335) (451 aa) fasta scores: E(): 7e-95, 63.15% id in 437 aa.
  
    0.652
dnaJ2
Chaperone protein 2; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
   
 0.603
dnaJ1
Chaperone protein cofactor 1; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between D [...]
   
 0.603
lysI
L-Lysine transport protein; Similar to Corynebacterium glutamicum L-Lysine transport protein LysI SW:LYSI_CORGL (P35865) (501 aa) fasta scores: E(): 9.3e-131, 69.85% id in 491 aa.
  
 
 0.567
dcuB
Similar to Escherichia coli anaerobic C4-dicarboxylate transporter DcuB or GenF or B4123 or Z5725 or ECS5105 SWALL:DCUB_ECOLI (SWALL:P14409) (446 aa) fasta scores: E(): 4.3e-91, 54.5% id in 444 aa, and to Wolinella succinogenes C4-dicarboxylate membrane transporter DcuB SWALL:Q9ZEN8 (EMBL:AJ131242) (452 aa) fasta scores: E(): 4e-94, 54.12% id in 449 aa.
  
    0.557
DIP0491
Putative secreted amino acid hydrolase; Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 6.4e-18, 36.39% id in 305 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 2.5e-11, 30.9% id in 330 aa. Also similar to DIP1587, 306 aa; fasta scores: E(): 1.1e-48, 52.303% identity in 304 aa overlap. Note: Contains a putative twin-arginine translocation (TAT) system recognition motif (RRSFLG) at the N-terminal region.
     
 0.526
trpC1
Similar to Corynebacterium glutamicum tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase trpC SW:TRPC_CORGL (P06560) (474 aa) fasta scores: E(): 7.5e-121, 70.15% id in 459 aa, and to Escherichia coli tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase TrpC or b1262 SW:TRPC_ECOLI (P00909) (452 aa) fasta scores: E(): 3.9e-58, 41.7% id in 482 aa. Note overlap with upstream gene suggesting possible downstream translational start codon; Belongs to the TrpF family.
  
  
 0.476
sdaB
L-serine dehydratase; Similar to Pseudomonas aeruginosa L-serine dehydratase SdaB or PA5379 SWALL:Q9HTI5 (EMBL:AE004950) (458 aa) fasta scores: E(): 3.5e-84, 53.99% id in 463 aa, and to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 3e-70, 49.24% id in 461 aa; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
  
 0.421
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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