STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdaAL-serine dehydratase 1; Similar to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SW:SDHL_ECOLI (P16095) (454 aa) fasta scores: E(): 4.8e-113, 63.08% id in 447 aa; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.959
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.952
trpB2
Tryptophan synthase beta chain TrpB2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.931
DIP1863
Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv3042c TR:AAK47457 (EMBL:AL021287) (409 aa) fasta scores: E(): 3.1e-69, 54.54% id in 407 aa, and to Mycobacterium leprae putative phosphoserine phosphatase ML1727 TR:Q9CBQ6 (EMBL:AL583923) (411 aa) fasta scores: E(): 6.2e-66, 53.82% id in 405 aa.
   
 
 0.926
trpB1
Tryptophan synthase beta chain TrpB1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.912
sdaB
L-serine dehydratase; Similar to Pseudomonas aeruginosa L-serine dehydratase SdaB or PA5379 SWALL:Q9HTI5 (EMBL:AE004950) (458 aa) fasta scores: E(): 3.5e-84, 53.99% id in 463 aa, and to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 3e-70, 49.24% id in 461 aa; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
  
 
0.907
cysE
Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 9.3e-33, 55.68% id in 167 aa, and to Azotobacter vinelandii O-acetylserine synthase CysE2 TR:O69218 (EMBL:AF010139) (251 aa) fasta scores: E(): 6.1e-38, 58.85% id in 175 aa.
     
 0.904
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
  0.901
sdaC
Similar to Escherichia coli serine transporter SdaC or DcrA or B2796 or Z4113 or ECS3656 SW:SDAC_ECOLI (P36559) (429 aa) fasta scores: E(): 4.6e-100, 61.66% id in 420 aa.
 
  
 0.837
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.822
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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