STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nagBPutative isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (259 aa)    
Predicted Functional Partners:
DIP0520
Putative deacetylase; Similar to Bacillus subtilis N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_BACSU (O34450) (396 aa) fasta scores: E(): 1.3e-23, 34.7% id in 389 aa, and to Escherichia coli, and N-acetylglucosamine-6-phosphate deacetylase NagA or B0677 or Z0824 or ECS0707 SW:NAGA_ECOLI (P15300) (382 aa) fasta scores: E(): 2.9e-18, 26.15% id in 390 aa.
 0.999
glmS
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
 0.940
glmM
Conserved hypothetical protein; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
    
 0.937
DIP0519
Putative epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
 
   
 0.923
pgi
Similar to Escherichia coli glucose-6-phosphate isomerase Pgi or B4025 or Z5623 or ECS5008 SW:G6PI_ECOLI (P11537) (549 aa) fasta scores: E(): 2e-104, 52.71% id in 552 aa, and to Mycobacterium tuberculosis glucose-6-phosphate isomerase Pgi or Rv0946c or MT0972 or MTCY10D7.28 SW:G6PI_MYCTU (P77895) (553 aa) fasta scores: E(): 2.6e-133, 62.75% id in 545 aa.
  
 
 0.917
DIP0689
Putative mannose-phosphate isomerase; Similar to Mycobacterium tuberculosis CDC1551 mannose-6-phosphate isomerase MT3353 TR:AAK47695 (EMBL:AE007145) (408 aa) fasta scores: E(): 1.6e-57, 47.43% id in 409 aa, and to Escherichia coli mannose-6-phosphate isomerase ManA or Pmi or B1613 SW:MANA_ECOLI (P00946) (391 aa) fasta scores: E(): 1.7e-24, 38.34% id in 399 aa.
     
 0.907
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
  
  
 0.851
DIP0518
Putative regulatory protein sugar kinase; Similar to Streptomyces coelicolor glucokinase Glk or SC6E10.20c SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 8e-13, 30.91% id in 317 aa.
 
   
 0.727
DIP0517
Putative GntR family regulatory protein; Similar to Escherichia coli galactonate operon transcriptional repressor DgoR or B3694/B3695 SW:DGOR_ECOLI (P31460) (229 aa) fasta scores: E(): 8.4e-09, 23.11% id in 199 aa.
     
 0.653
glmU
Putative UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.
     
 0.507
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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