STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa)    
Predicted Functional Partners:
secY
Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
  
  
 0.973
purB
Similar to Homo sapiens adenylosuccinate lyase AdsL SW:PUR8_HUMAN (P30566) (484 aa) fasta scores: E(): 3.3e-39, 33.19% id in 470 aa, and to Corynebacterium ammoniagenes adenylosuccino lyase PurB TR:Q9RHX3 (EMBL:AB003161) (479 aa) fasta scores: E(): 4.4e-148, 82.91% id in 480 aa.
   
 0.959
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.937
nrdE
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.926
ndk
Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
 
 0.921
pyk
Pyruvate kinase; Similar to Corynebacterium glutamicum pyruvate kinase Pyk SW:KPYK_CORGL (Q46078) (475 aa) fasta scores: E(): 1.3e-146, 83.36% id in 469 aa, and to Bacillus psychrophilus pyruvate kinase Pyk SW:KPYK_BACPY (P51182) (586 aa) fasta scores: E(): 6.9e-64, 41.45% id in 480 aa.
  
 0.910
nrdF1
Ribonucleotide reductase beta-chain 1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
     
 0.909
nrdF2
Similar to Escherichia coli ribonucleoside-diphosphate reductase 2 beta chain NrdF SW:RIR4_ECOLI (P37146) (319 aa) fasta scores: E(): 5.4e-72, 56.74% id in 319 aa, and to Mycobacterium leprae ribonucleoside-diphosphate reductase beta chain ML1731 SW:RIR2_MYCLE (Q9CBQ2) (325 aa) fasta scores: E(): 1.5e-74, 61.12% id in 319 aa. Note: Also similar to DIP1865 (328 aa) fasta scores: E(): 5.7e-71, 54.799% identity in 323 aa overlap.
     
 0.907
rpsK
30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
 
 
 0.906
hpt
Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 5.3e-28, 48.21% id in 168 aa, and to Mycobacterium leprae hypoxanthine-guanine phosphoribosyltransferase ML0214 SW:HPRT_MYCLE (O69537) (203 aa) fasta scores: E(): 3.2e-40, 55.31% id in 188 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.904
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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