STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0544Putative secreted protein; Similar to Streptomyces coelicolor putative secreted protein 3SC5B7.14c TR:Q9EWT5 (EMBL:AL449216) (231 aa) fasta scores: E(): 9.9e-08, 30.99% id in 242 aa. (269 aa)    
Predicted Functional Partners:
DIP2269
Hypothetical protein; No significant database matches.
  
     0.710
infA
Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
       0.588
DIP0543
Putative sialidase precursor; Similar to Micromonospora viridifaciens sialidase precursor NedA SW:NANH_MICVI (Q02834) (647 aa) fasta scores: E(): 4e-06, 33.62% id in 455 aa. Note: Contains a potential colied-coil region at residues 518..639.
       0.584
DIP1801
Conserved hypothetical protein; Limited database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2474c TR:O53201 (EMBL:AL021246) (217 aa) fasta scores: E(): 2.2e-14, 39.59% id in 197 aa.
  
     0.581
mapA
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
       0.529
DIP1842
Putative membrane protein; Poor database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2520c TR:O53225 (EMBL:AL021185) (75 aa) fasta scores: E(): 2.7e-06, 45.33% id in 75 aa.
 
     0.524
DIP2134
Conserved hypothetical protein; N-terminus similar to those from other actinomycetes eg. Saccharopolyspora erythraea Orf122 protein TR:Q54106 (EMBL:X92556) (121 aa) fasta scores: E(): 0.0076, 31.15% id in 138 aa, and to Streptomyces coelicolor hypothetical 30.8 kDa protein SCE6.30c TR:Q9KZR0 (EMBL:AL353832) (277 aa) fasta scores: E(): 0.02, 36.76% id in 68 aa.
 
     0.498
rpsM
30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.
       0.496
rpsK
30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
       0.496
DIP0359
Putative secreted hydrolase; Low similarity to Streptomyces scabies esterase precursor EstA SW:ESTA_STRSC (P22266) (345 aa) fasta scores: E(): 0.12, 26.28% id in 331 aa.
 
   
 0.495
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.