STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0554Putative subtilisin-like cell wall associated serine protease (mycosin); Similar to Streptomyces coelicolor serine protease SC3C3.08 TR:O86642 (EMBL:AL031231) (413 aa) fasta scores: E(): 4e-11, 32.37% id in 278 aa and to Mycobacterium tuberculosis hypothetical 46.0 kDa protein Rv3449 or MTCY13E12.02 or MT3555 SWALL:O06316 (EMBL:Z95390) (455 aa) fasta scores: E(): 4.7e-10, 38.11% id in 307 aa. (299 aa)    
Predicted Functional Partners:
DIP0556
Similar to Mycobacterium tuberculosis CDC1551 FtsK/SpoIIIE family protein MT3553 TR:AAK47893 (EMBL:AE007159) (1200 aa) fasta scores: E(): 1.7e-97, 37.59% id in 1221 aa.
 
 
 0.937
DIP0555
Putative surface-anchored membrane protein; Very low similarity to Mycobacterium tuberculosis hypothetical protein Rv3448 or MTCY77.20 or MT3554 SWALL:O33354 (EMBL:Z95390) (467 aa) fasta scores: E(): 0.0016, 21.96% id in 478 aa. Note: Contains a putative sortase anchor site (LPNTG).
  
  
 0.873
DIP1784
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv2446c TR:O53173 (EMBL:AL021246) (123 aa) fasta scores: E(): 1.5e-07, 31.35% id in 118 aa, and to Mycobacterium leprae conserved membrane protein ML1470 TR:Q9CBY9 (EMBL:AL583922) (123 aa) fasta scores: E(): 4.9e-07, 30.46% id in 128 aa.
      
 0.705
DIP0552
Conserved hypothetical protein; Low similarity to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3556 TR:AAK47896 (EMBL:AE007159) (482 aa) fasta scores: E(): 8.1e-16, 29.36% id in 487 aa.
 
 
 0.682
esxB
Very low similarity to Mycobacterium tuberculosis hypothetical 13.5 kDa protein Rv3445c or MTCY77.17c TR:O06262 (EMBL:Z95389) (125 aa) fasta scores: E(): 0.0007, 31.52% id in 92 aa; Belongs to the WXG100 family. CFP-10 subfamily.
  
  
 0.651
esxA
Similar to Mycobacterium tuberculosis hypothetical 11.1 kDa protein Rv3444c or MTCY77.16c TR:O06261 (EMBL:Z95389) (100 aa) fasta scores: E(): 1e-08, 35.48% id in 93 aa; Belongs to the WXG100 family. ESAT-6 subfamily.
  
  
 0.600
DIP0557
Putative membrane protein; No significant database matches.
       0.569
secY
Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
    
 
 0.549
DIP1684
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 29.8 kDa protein Rv2235 precursor or MT2294 or MTCY427.16 SW:YM35_MYCTU (Q10517) (271 aa) fasta scores: E(): 1.4e-34, 38.54% id in 275 aa.
    
   0.544
DIP1638
Putative oxidoreductase; Similar to Saccharopolyspora erythraea ORF1, 5' end; NADH-ferredoxin oxidoreductase (fragment) TR:Q54100 (EMBL:L38646) (93 aa) fasta scores: E(): 1.9e-08, 42.16% id in 83 aa.
  
 0.531
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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