Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
glmMConserved hypothetical protein; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (447 aa)    
Predicted Functional Partners:
glmU
Putative UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.
 
  
 0.980
glmS
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
 
 
 0.980
nagB
Putative isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
    
 0.937
DIP0520
Putative deacetylase; Similar to Bacillus subtilis N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_BACSU (O34450) (396 aa) fasta scores: E(): 1.3e-23, 34.7% id in 389 aa, and to Escherichia coli, and N-acetylglucosamine-6-phosphate deacetylase NagA or B0677 or Z0824 or ECS0707 SW:NAGA_ECOLI (P15300) (382 aa) fasta scores: E(): 2.9e-18, 26.15% id in 390 aa.
     
 0.935
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
  
 0.682
cysS2
cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
      
 0.678
DIP0985
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 34.0 kDa protein SCD95A.25c TR:Q9KXU9 (EMBL:AL357432) (314 aa) fasta scores: E(): 2.9e-29, 47.67% id in 258 aa, and to Methanothermobacter thermautotrophicus dolichyl-phosphate mannose synthase related protein MTH374 TR:O26474 (EMBL:AE000823) (291 aa) fasta scores: E(): 1.4e-08, 31.89% id in 254 aa.
   
  
 0.676
DIP0565
Hypothetical protein; No significant database matches. High concentration of alanine, glycine and proline residues.
       0.665
rpsI
30S ribosomal protein S9; Similar to Mycobacterium tuberculosis 30S ribosomal protein S9 RpsI or Rv3442c or MT3547 or MTCY77.14c SW:RS9_MYCTU (O06259) (151 aa) fasta scores: E(): 8.2e-33, 66.89% id in 145 aa; Belongs to the universal ribosomal protein uS9 family.
  
    0.636
DIP0361
Putative bifunctional protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
  
 
 0.626
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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