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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0581Conserved hypothetical protein; Similar to Corynebacterium ammoniagenes GuaB, ORF genes for IMP dehydrogenase, hypothetical protein TR:Q9RHY9 (EMBL:AB003154) (376 aa) fasta scores: E(): 3.5e-63, 67.18% id in 387 aa, and C-terminal region similar to Escherichia coli inosine-5'-monophosphate dehydrogenase GuaB or GuaR or B2508 or Z3772 or ECS3370 SW:IMDH_ECOLI (P06981) (488 aa) fasta scores: E(): 0.00061, 31.49% id in 181 aa. (381 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolysing]; Catalyzes the synthesis of GMP from XMP.
 
 0.996
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.980
purH
Similar to Mycobacterium tuberculosis bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydorlase (EC 3.5.4.10)] or Rv0957 or MT0984 or MTCY10D7.17c SW:PUR9_MYCTU (P71553) (523 aa) fasta scores: E(): 1e-137, 68.06% id in 526 aa, and to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydrolase (EC 3.5.4.10)] PurH or B4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1e-58, 45.25% id in 537 aa.
  
 0.980
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.965
DIP1285
Conserved hypothetical protein; Similar to Rhizobium loti Mll8746 protein SWALL:Q989X1 (EMBL:AP003008) (280 aa) fasta scores: E(): 3.4e-12, 28.57% id in 210 aa, and to Xylella fastidiosa GMP synthase XF0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 8.5e-09, 26.97% id in 215 aa.
  
 
 0.936
DIP1850
Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.912
hpt
Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 5.3e-28, 48.21% id in 168 aa, and to Mycobacterium leprae hypoxanthine-guanine phosphoribosyltransferase ML0214 SW:HPRT_MYCLE (O69537) (203 aa) fasta scores: E(): 3.2e-40, 55.31% id in 188 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.908
DIP1693
Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily.
     
  0.900
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.787
DIP2057
Putative phosphoribosylglycinamide formyltransferase; Similar to although shorter in its N-terminal region than Pasteurella haemolytica probable phosphoribosylglycinamide formyltransferase 2 PurT or Mpa1 SWALL:PURT_PASHA (SWALL:P46927) (392 aa) fasta scores: E(): 1e-12, 32.24% id in 276 aa, than Bacillus subtilis phosphoribosylglycinamide formyltransferase 2 PurT SWALL:PURT_BACSU (SWALL:P39771) (384 aa) fasta scores: E(): 3.8e-12, 35.81% id in 282 aa, and than Escherichia coli phosphoribosylglycinamide formyltransferase 2 PurT or B1849 SWALL:PURT_ECOLI (SWALL:P33221) (391 aa) fasta sco [...]
    
   0.709
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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