STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0625Putative membrane protein; Similar to the C-terminal region of Corynebacterium ulcerans HtaA TR:Q9EZ58 (EMBL:AF304009) (410 aa) fasta scores: E(): 4.9e-58, 54.14% id in 410 aa, and to Streptomyces coelicolor hypothetical 48.2 kDa protein SCC75A.17c TR:Q9RKQ7 (EMBL:AL133220) (477 aa) fasta scores: E(): 4.9e-06, 26.25% id in 579 aa. (591 aa)    
Predicted Functional Partners:
hmuT
Iron-related transport system receptor precursor protein; Identical to previously sequenced Corynebacterium diphtheriae HmuT precursor TR:Q9XD89 (EMBL:AF109162) (353 aa) fasta scores: E(): 3.9e-123, 98.86% id in 353 aa, and highly similar to Corynebacterium ulcerans hemin receptor precursor HmuT TR:Q9EZ57 (EMBL:AF304009) (351 aa) fasta scores: E(): 2.6e-99, 79.83% id in 352 aa.
 
  
 0.993
DIP0624
Putative membrane protein; No significant database matches.
  
  
 0.941
hmuV
Iron-related transport system ATP-binding protein; Almost identical to the previously sequenced Corynebacterium diphtheriae HmuV TR:Q9XD87 (EMBL:AF109162) (277 aa) fasta scores: E(): 3.2e-88, 97.83% id in 277 aa, and to Escherichia coli iron (III) dicitrate transport ATP-binding protein FecE or B4287 SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 1.2e-23, 41.94% id in 236 aa.
 
  
 0.925
hmuU
Iron-related transport system membrane protein; Almost identical to previously sequenced Corynebacterium diphtheriae HmuU TR:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 6.1e-120, 98% id in 350 aa, and highly similar to Corynebacterium ulcerans permease HmuU TR:Q9EZ56 (EMBL:AF304009) (350 aa) fasta scores: E(): 4.3e-100, 81.14% id in 350 aa; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
  
 0.853
DIP0629
Membrane protein; Almost identical to previously sequenced Corynebacterium diphtheriae secreted protein precursor TR:Q9XD85 (EMBL:AF109162) (339 aa) fasta scores: E(): 2.9e-99, 89.21% id in 306 aa.
     
 0.838
DIP0565
Hypothetical protein; No significant database matches. High concentration of alanine, glycine and proline residues.
  
     0.655
hmuO
Heme oxygenase; Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.
 
  
 0.629
DIP1519
Putative membrane protein; Similar to Corynebacterium diphtheriae secreted protein precursor TR:Q9XD85 (EMBL:AF109162) (339 aa) fasta scores: E(): 2.7e-34, 42.4% id in 250 aa.
     
 0.616
crcB1
Putative membrane protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
  
     0.590
DIP1059
Similar to Streptomyces coelicolor putative iron-siderophore uptake system ATP-binding component SCI51.25C TR:Q9S215 (EMBL:AL109848) (301 aa) fasta scores: E(): 1.9e-42, 50.58% id in 255 aa, and to Escherichia coli ferric enterobactin transport ATP-binding protein fepC b0588 SW:FEPC_ECOLI (P23878) (271 aa) fasta scores: E(): 1.1e-41, 49.61% id in 262 aa.
   
  
 0.587
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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