STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
DIP0630Putative methionine biosynthesis-related protein; Similar to Mycobacterium tuberculosis CDC1551 transulfuration enzyme family protein MT3443 TR:AAK47787 (EMBL:AE007151) (449 aa) fasta scores: E(): 4.8e-93, 56.94% id in 432 aa, and to Pseudomonas aeruginosa O-succinylhomoserine sulfhydrylase MetZ or PA3107 SW:METZ_PSEAE (P55218) (403 aa) fasta scores: E(): 2.7e-26, 39.31% id in 435 aa. (438 aa)    
Predicted Functional Partners:
metX
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 
 0.996
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.967
metE
Similar to fragment of Mycobacterium tuberculosis 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE or Rv1133c or MT1165 or MTC22G8.22 SW:METE_MYCTU (O06584) (759 aa) fasta scores: E(): 2.5e-06, 70.732% id in 41 aa, and to Streptomyces griseus subspgriseus. 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase- like protein TR:Q9KHC5 (EMBL:AF263012) (774 aa) fasta scores: E(): 4.1e-06, 77.778% id in 36 aa, and to Saccharomyces cerevisiae 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Met6 or YER091c SW:METE_YEAST (P05694) ( [...]
  
 
 0.941
aecD
Beta C-S lyase; Similar to Corynebacterium glutamicum beta C-S lyase AecD TR:Q46061 (EMBL:M89931) (325 aa) fasta scores: E(): 3e-66, 53.93% id in 330 aa.
   
 0.936
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
     
 0.909
DIP1890
Putative cysteine synthase; Similar to the C-terminal region of Arabidopsis thaliana cysteine synthase, mitochondrial precursor ACS 1 SW:CYSM_ARATH (Q43725) (424 aa) fasta scores: E(): 1.5e-58, 53.39% id in 309 aa, and to the full length Neisseria meningitidis (serogroup A) putative cysteine synthase NMA0974 TR:Q9JQL6 (EMBL:AL162754) (310 aa) fasta scores: E(): 5.6e-65, 59.09% id in 308 aa.
  
 
 0.856
thrA
Similar to Corynebacterium glutamicum homoserine dehydrogenase Hom or ThrA SW:DHOM_CORGL (P08499) (445 aa) fasta scores: E(): 4.2e-117, 75.28% id in 437 aa, and to Bacillus subtilis homoserine dehydrogenase Hom or Tdm SW:DHOM_BACSU (P19582) (433 aa) fasta scores: E(): 4.2e-54, 40.18% id in 433 aa.
  
 
 0.846
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
  0.808
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
  0.807
DIP2056
Similar to Streptomyces coelicolor putative ferredoxin/ferredoxin-NADP reductase SCF15.02 SWALL:Q9RK35 (EMBL:AL132856) (454 aa) fasta scores: E(): 4e-107, 59.95% id in 452 aa, and to Rattus norvegicus NADPH:adrenodoxin oxidoreductase, mitochondrial precursor FdxR SWALL:ADRO_RAT (SWALL:P56522) (494 aa) fasta scores: E(): 1.3e-42, 36.02% id in 458 aa, and to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase FprB or Rv0886 or MT0909 or MTCY31.14 SWALL:FPRB_MYCTU (SWALL:Q10547) (575 aa) fasta scores: E(): 2.1e-33, 35.98% id in 453 aa.
   
    0.755
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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