STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0630Putative methionine biosynthesis-related protein; Similar to Mycobacterium tuberculosis CDC1551 transulfuration enzyme family protein MT3443 TR:AAK47787 (EMBL:AE007151) (449 aa) fasta scores: E(): 4.8e-93, 56.94% id in 432 aa, and to Pseudomonas aeruginosa O-succinylhomoserine sulfhydrylase MetZ or PA3107 SW:METZ_PSEAE (P55218) (403 aa) fasta scores: E(): 2.7e-26, 39.31% id in 435 aa. (438 aa)    
Predicted Functional Partners:
metX
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 
 0.994
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.970
aecD
Beta C-S lyase; Similar to Corynebacterium glutamicum beta C-S lyase AecD TR:Q46061 (EMBL:M89931) (325 aa) fasta scores: E(): 3e-66, 53.93% id in 330 aa.
   
 0.943
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 
 0.935
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
     
 0.908
DIP1890
Putative cysteine synthase; Similar to the C-terminal region of Arabidopsis thaliana cysteine synthase, mitochondrial precursor ACS 1 SW:CYSM_ARATH (Q43725) (424 aa) fasta scores: E(): 1.5e-58, 53.39% id in 309 aa, and to the full length Neisseria meningitidis (serogroup A) putative cysteine synthase NMA0974 TR:Q9JQL6 (EMBL:AL162754) (310 aa) fasta scores: E(): 5.6e-65, 59.09% id in 308 aa.
  
 
 0.879
thrA
Similar to Corynebacterium glutamicum homoserine dehydrogenase Hom or ThrA SW:DHOM_CORGL (P08499) (445 aa) fasta scores: E(): 4.2e-117, 75.28% id in 437 aa, and to Bacillus subtilis homoserine dehydrogenase Hom or Tdm SW:DHOM_BACSU (P19582) (433 aa) fasta scores: E(): 4.2e-54, 40.18% id in 433 aa.
  
 
 0.846
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
  0.808
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
  0.808
DIP2056
Similar to Streptomyces coelicolor putative ferredoxin/ferredoxin-NADP reductase SCF15.02 SWALL:Q9RK35 (EMBL:AL132856) (454 aa) fasta scores: E(): 4e-107, 59.95% id in 452 aa, and to Rattus norvegicus NADPH:adrenodoxin oxidoreductase, mitochondrial precursor FdxR SWALL:ADRO_RAT (SWALL:P56522) (494 aa) fasta scores: E(): 1.3e-42, 36.02% id in 458 aa, and to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase FprB or Rv0886 or MT0909 or MTCY31.14 SWALL:FPRB_MYCTU (SWALL:Q10547) (575 aa) fasta scores: E(): 2.1e-33, 35.98% id in 453 aa.
   
    0.761
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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