STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0633Similar to Streptomyces coelicolor putative exodeoxyribonuclease SCE87.25c TR:Q9RKB3 (EMBL:AL132674) (274 aa) fasta scores: E(): 2.6e-27, 44.3% id in 307 aa. (301 aa)    
Predicted Functional Partners:
DIP2047
Putative exonuclease; Similar to Streptomyces coelicolor putative exonuclease SC3A7.09 SWALL:O86610 (EMBL:AL031155) (259 aa) fasta scores: E(): 4.4e-32, 51.93% id in 258 aa, and to Mycobacterium tuberculosis CDC1551 exodeoxyribonuclease III MT0442 SWALL:AAK44665 (EMBL:AE006947) (291 aa) fasta scores: E(): 1.2e-25, 54.16% id in 264 aa.
  
  
  0.975
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.967
DIP0632
Putative membrane protein; Similar to Rhizobium meliloti putative transport transmembrane protein SMC02161 TR:CAC41922 (EMBL:AL591783) (411 aa) fasta scores: E(): 5.7e-56, 46.61% id in 384 aa, and to Streptomyces coelicolor putative transmembrane efflux protein SC1G2.16c TR:Q9RDR3 (EMBL:AL136500) (413 aa) fasta scores: E(): 4.7e-46, 41.62% id in 370 aa.
       0.831
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.819
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
   
 0.736
DIP1195
Putative pseudouridine synthase B; Similar to Mycobacterium tuberculosis hypothetical 27.6 kDa protein Rv1711 or MT1751.1 or MTCI125.33 SWALL:YH11_MYCTU (SWALL:O33210) (254 aa) fasta scores: E(): 2.8e-52, 60.74% id in 242 aa, and to Bacillus subtilis ribosomal large subunit pseudouridine synthase B RluB SWALL:RLUB_BACSU (SWALL:P35159) (229 aa) fasta scores: E(): 2e-28, 46.72% id in 229 aa. Note: Alternative start codon at residue 55.
  
    0.700
icd
Isocitrate dehydrogenase [NADP]; Highly similar to Corynebacterium glutamicum isocitrate dehydrogenase [NADP] Icd SW:IDH_CORGL (P50216) (738 aa) fasta scores: E(): 0, 83.31% id in 737 aa; Belongs to the monomeric-type IDH family.
  
    0.691
DIP0331
Conserved hypothetical protein; Similar to Klebsiella oxytoca YiaX1 TR:AAK69523 (EMBL:AF282849) (315 aa) fasta scores: E(): 4.4e-18, 31.94% id in 313 aa.
    
 
 0.653
DIP1980
Putative DNA repair protein; Similar to Mycobacterium leprae probable DNA glycosylase ML1920 TR:Q9CBJ0 (EMBL:AL583923) (297 aa) fasta scores: E(): 5.3e-52, 51.86% id in 295 aa. N-terminus is similar to the N-terminal region of Escherichia coli A/G-specific adenine glycosylase MutY SW:MUTY_ECOLI (P17802) (350 aa) fasta scores: E(): 2.9e-23, 40.48% id in 205 aa.
    
 0.650
trpS
tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.539
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.