Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0638Conserved hypothetical protein; Low similarity to C-terminal region of Streptomyces coelicolor putative adenosine deaminase SC5H1.24c TR:Q9X7T2 (EMBL:AL049863) (359 aa) fasta scores: E(): 2.1e-06, 28.88% id in 225 aa. (314 aa)    
Predicted Functional Partners:
deoD
Putative transposase (pseudogene); Possible inverted repeat.
     
 0.906
iunH
Similar to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 2.3e-73, 64.19% id in 310 aa.
  
 
 0.905
DIP2340
Similar to members of a family of nucleoside hydrolases eg. Mycobacterium tuberculosis nucleoside hydrolase IunH or Rv3393 or MTV004.51 SWALL:O50418 (EMBL:AL009198) (308 aa) fasta scores: E(): 7.6e-27, 36.07% id in 316 aa, and to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SWALL:IUNH_CRIFA (SWALL:Q27546) (314 aa) fasta scores: E(): 2.7e-14, 28.07% id in 317 aa.
  
 
 0.905
DIP1594
Conserved hypothetical protein; Similar to Corynebacterium glutamicum hypothetical 26.0 kDa protein in FtsZ 3'region SW:YFTZ_CORGL (P94338) (246 aa) fasta scores: E(): 6.5e-66, 68.72% id in 243 aa, and to Streptomyces griseus hypothetical 25.3 kDa protein in FtsZ 3'region SW:YFTZ_STRGR (P45496) (246 aa) fasta scores: E(): 7.4e-41, 50% id in 228 aa; Belongs to the multicopper oxidase YfiH/RL5 family.
    
  0.900
DIP1693
Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily.
     
  0.900
DIP0637
Putative peptidoglycan synthesis related protein; Similar to Mycobacterium leprae putative D-alanyl-D-alanine carboxypeptidase ML0691 TR:Q9CCM2 (EMBL:AL583919) (411 aa) fasta scores: E(): 6.2e-45, 40.1% id in 389 aa, and to Bacillus subtilis penicillin-binding protein 5* precursor DacB SW:DACB_BACSU (P35150) (382 aa) fasta scores: E(): 2e-13, 30.26% id in 261 aa; Belongs to the peptidase S11 family.
       0.695
cobK
precorrin-6X reductase; Similar to Rhodococcus erythropolis precorrin-6X reductase CobK SWALL:COBK_RHOER (SWALL:Q53139) (248 aa) fasta scores: E(): 1.6e-41, 50% id in 244 aa, and to Mycobacterium tuberculosis precorrin-6X reductase CobK or Rv2070c or MT2130 or MTCY49.09c SWALL:COBK_MYCTU (SWALL:Q10680) (244 aa) fasta scores: E(): 1.2e-36, 47.54% id in 244 aa.
      
 0.654
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
      
 0.635
guaA
GMP synthase [glutamine-hydrolysing]; Catalyzes the synthesis of GMP from XMP.
  
  
 0.623
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
 
 0.601
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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