STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lpdASimilar to Mycobacterium tuberculosis dihydrolipoamide dehydrogenase LpdA or Rv3303c or MTV016.02c TR:O53355 (EMBL:AL021841) (493 aa) fasta scores: E(): 5.8e-110, 64.04% id in 470 aa, and to Bacillus subtilis dihydrolipoamide dehydrogenase PdhD or AceD or CitL SW:DLD1_BACSU (P21880) (470 aa) fasta scores: E(): 1.2e-36, 31.47% id in 467 aa. (490 aa)    
Predicted Functional Partners:
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...]
  
 0.994
pdhC
Similar to Acholeplasma laidlawii dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_ACHLA (P35489) (544 aa) fasta scores: E(): 8.7e-49, 37.7% id in 541 aa, to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB or Rv2215 or MT2272 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 8.9e-95, 58.49% id in 559 aa, and to Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_BACST (P11961) (427 aa) fasta [...]
 
 0.949
DIP0644
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 hydrolase, Ama/HipO/HyuC family MT3404 TR:AAK47747 (EMBL:AE007149) (389 aa) fasta scores: E(): 4.5e-74, 49.74% id in 388 aa.
       0.743
glpD
Similar to Mycobacterium leprae glycerol-3-phosphate dehydrogenase GlpD or ML0713 or L308_C1_179 SW:GLPD_MYCLE (P53435) (585 aa) fasta scores: E(): 5.7e-116, 55.35% id in 560 aa, and to Escherichia coli aerobic glycerol-3-phosphate dehydrogenase GlpD or GlyD or B3426 SW:GLPD_ECOLI (P13035) (501 aa) fasta scores: E(): 2.4e-38, 33.67% id in 493 aa.
  
  
 0.704
cobM
Similar to Pseudomonas denitrificans precorrin-4 C11-methyltransferase CobM SWALL:COBM_PSEDE (SWALL:P21922) (253 aa) fasta scores: E(): 5.4e-46, 55.37% id in 251 aa, and to Rhodococcus erythropolis precorrin-4 C11-methyltransferase CobM SWALL:COBM_RHOER (SWALL:Q53138) (249 aa) fasta scores: E(): 3.4e-57, 61.04% id in 249 aa.
      
 0.678
pyrF
Similar to Mycobacterium leprae orotidine 5'-phosphate decarboxylase PyrF or ML0537 SWALL:Q9CCR1 (EMBL:AL583918) (282 aa) fasta scores: E(): 7.5e-48, 53.13% id in 271 aa, and to Streptomyces coelicolor orotidine 5'-phosphate decarboxylase PyrF or SC9C5.05c SWALL:Q9KXR8 (EMBL:AL357523) (278 aa) fasta scores: E(): 2.9e-44, 48.14% id in 270 aa; Belongs to the OMP decarboxylase family. Type 2 subfamily.
      
 0.678
DIP0643
Putative DNA-binding protein; No significant database matches.
       0.614
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.594
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.594
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
  
 0.584
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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