STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0656Putative transcriptional regulatory protein; Similar to Streptomyces coelicolor probable lacI-family transcriptional regulator SCC57A.16 TR:Q9RDI2 (EMBL:AL136519) (347 aa) fasta scores: E(): 5.5e-32, 34.04% id in 326 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SW:CCPA_BACME (P46828) (332 aa) fasta scores: E(): 5.1e-24, 29.17% id in 329 aa. (351 aa)    
Predicted Functional Partners:
rbsK
Putative ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
 0.862
DIP1435
Putative fructose-specific IIBC (PTS system) (pseudogene); HMMPfam hit to PF02378, Phosphotransferase system, EIIC.
 
 
 
 0.759
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
  
  
 0.746
DIP2336
Similar to but longer than a family of hypothetical proteins eg. Deinococcus radiodurans conserved hypothetical protein DRB0052 SWALL:Q9RZR3 (EMBL:AE001826) (133 aa) fasta scores: E(): 8.8e-10, 43.75% id in 128 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0607 or SAV0652 SWALL:Q99VW9 (EMBL:AP003131) (120 aa) fasta scores: E(): 1.3e-09, 42.73% id in 117 aa.
   
 
 0.727
DIP0022
Similar to Streptomyces coelicolor probable ABC transport protein, membrane component SC8F11.06 TR:Q9KZH2 (EMBL:AL353864) (359 aa) fasta scores: E(): 1.1e-72, 57.66% id in 326 aa; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.670
DIP0021
Similar to Streptomyces coelicolor probable solute-binding lipoprotein SC8F11.05 TR:Q9KZH3 (EMBL:AL353864) (340 aa) fasta scores: E(): 2.8e-63, 54.98% id in 331 aa.
 
  
 0.597
DIP2241
Similar to Streptomyces coelicolor putative GntR-family transcriptional regulator SC7E4.28c TR:Q9K492 (EMBL:AL359214) (254 aa) fasta scores: E(): 7.3e-21, 34.82% id in 224 aa, and to Escherichia coli fatty acyl responsive regulator FarR or G30 or B0730 SW:FARR_ECOLI (P13669) (240 aa) fasta scores: E(): 6.4e-14, 30.93% id in 236 aa.
  
   
 0.591
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
   0.556
DIP1746
Similar to Escherichia coli xylulose kinase XylB or B3564 SW:XYLB_ECOLI (P09099) (484 aa) fasta scores: E(): 6.8e-22, 30.57% id in 471 aa.
 
 
 
 0.525
DIP1429
Putative sugar related operon transcriptional regulator (PTS system); Similar to Spiroplasma citri transcriptional regulator FruR TR:Q9RMF6 (EMBL:AF202665) (233 aa) fasta scores: E(): 7.3e-17, 33.75% id in 237 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 4e-13, 30% id in 240 aa. Note: Similar also to the upstream CDIP1427 258 aa, 41.634% identity in 257 aa overlap.
  
   
 0.513
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.