STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pccB1Propionyl CoA carboxylase beta chain 1; Similar to Corynebacterium glutamicum DtsR2 protein TR:O87201 (EMBL:AB018531) (537 aa) fasta scores: E(): 2e-182, 87.87% id in 536 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PccB SW:PCCB_SACER (P53003) (546 aa) fasta scores: E(): 5.2e-137, 64.83% id in 546 aa. Possible duplication of DIP0660 (69.309% identity in 492 aa overlap). (543 aa)    
Predicted Functional Partners:
accBC
Similar to Corynebacterium glutamicum acyl coenzyme A carboxylase AccBC TR:P71122 (EMBL:U35023) (591 aa) fasta scores: E(): 1.5e-188, 85.47% id in 592 aa, and to Mycobacterium leprae acetyl-/propionyl-coenzyme A carboxylase alpha chain [includes: biotin carboxylase (EC 6.3.4.14); biotin carboxyl carrier protein(BCCP)] BccA or ML0726 or B1308_C1_129 SW:BCCA_MYCLE (P46392) (598 aa) fasta scores: E(): 1.1e-159, 72.46% id in 592 aa.
 
 0.992
pycB
Similar to Methanococcus jannaschii pyruvate carboxylase subunit B PycB or MJ1231 SW:PYCB_METJA (Q58628) (567 aa) fasta scores: E(): 1.8e-88, 50.81% id in 490 aa, and to Propionibacterium freudenreichii shermanii biotin carboxyl carrier protein of methylmalonyl-CoA carboxyl-transferase TR:Q05618 (EMBL:L06488) (519 aa) fasta scores: E(): 1.2e-108, 66.15% id in 520 aa.
    
 0.905
pta
Phosphate acetyltransferase; Highly similar in its C-terminal region to Corynebacterium glutamicum phosphate acetyltransferase Pta SWALL:PTA_CORGL (SWALL:P77844) (329 aa) fasta scores: E(): 6.9e-94, 78.22% id in 326 aa, similar to the C-terminal region of Mycobacterium tuberculosis phosphate acetyltransferase Pta or Rv0408 or MT0421 or MTCY22G10.04 SWALL:PTA_MYCTU (SWALL:P96254) (690 aa) fasta scores: E(): 4.8e-68, 48.67% id in 452 aa, and similar to the C-terminal region of Escherichia coli phosphate acetyltransferase Pta or B2297 SWALL:PTA_ECOLI (SWALL:P39184) (713 aa) fasta scores: [...]
     
  0.900
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
  
  
 0.891
DIP2079
Similar to many putative oxidoreductases e.g. Rhizobium meliloti putative oxidoreductase protein R01702 or SMC00274 SWALL:CAC46281 (EMBL:AL591788) (295 aa) fasta scores: E(): 7.6e-30, 41.4% id in 285 aa, and to Escherichia coli hypothetical oxidoreductase YgbJ or B2736 SWALL:YGBJ_ECOLI (SWALL:Q46888) (302 aa) fasta scores: E(): 2e-26, 36.08% id in 291 aa.
   
 
  0.801
DIP1057
Putative methylmalonyl-CoA epimerase; Similar to Mycobacterium leprae B1549_F2_87 ML1157 TR:Q49717 (EMBL:U00014) (155 aa) fasta scores: E(): 1.2e-28, 55.47% id in 137 aa, and to Mycobacterium tuberculosis CDC1551 4-hydroxyphenylpyruvate dioxygenase C terminal domain containing protein MT1364 TR:AAK45627 (EMBL:AE007009) (152 aa) fasta scores: E(): 3e-27, 53.28% id in 137 aa, and to Pyrococcus horikoshii methylmalonyl-CoA epimerase PHO272 TR:AAK52053 (EMBL:AF364548) (136 aa) fasta scores: E(): 9.8e-13, 38.63% id in 132 aa, and to Homo sapiens methylmalonyl-CoA epimerase TR:AAK52052 (EMBL [...]
 
 
 0.791
DIP0657
Hypothetical protein; No significant database matches.
     
 0.665
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 
  0.609
DIP2189
Putative polyketide synthase; Similar to Mycobacterium tuberculosis polyketide synthase PKS13 or Rv3800c or MTV026.05c TR:O53579 (EMBL:AL022076) (1733 aa) fasta scores: E(): 5.4e-109, 44.5% id in 1719 aa, and to Polyangium cellulosum soraphen polyketide synthase A SorA TR:Q9ADL6 (EMBL:U24241) (6315 aa) fasta scores: E(): 6.2e-101, 35.96% id in 1090 aa.
  
  
 0.572
DIP0661
Putative biotin synthesis-related regulatory protein; Similar to C-terminal region of Escherichia coli BirA bifunctional protein BirA or BioR or DhbB or B3973 SW:BIRA_ECOLI (P06709) (321 aa) fasta scores: E(): 2e-15, 32.12% id in 221 aa.
  
 
 0.570
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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