STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (431 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.995
DIP1347
Similar to Mycobacterium leprae putative shikimate 5-dehydrogenase AroE or ML0515 SWALL:Q9CCS7 (EMBL:AL583918) (278 aa) fasta scores: E(): 5e-33, 45.42% id in 273 aa, and to Bacillus subtilis shikimate 5-dehydrogenase AroD SWALL:AROE_BACSU (SWALL:P54374) (280 aa) fasta scores: E(): 1.2e-13, 28.36% id in 282 aa.
  
 0.993
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.990
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.977
cmk
Cytidylate kinase; Similar to Mycobacterium tuberculosis cytidylate kinase Cmk or Rv1712 or MT1752 or MTCI125.34 SWALL:KCY_MYCTU (SWALL:O33211) (230 aa) fasta scores: E(): 1.9e-35, 55.45% id in 220 aa, and to Escherichia coli cytidylate kinase Cmk or MssA or B0910 or Z1256 or ECS0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 9.7e-25, 43.54% id in 209 aa.
 
  
 0.920
DIP0705
Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
 
   
 0.908
DIP1006
Similar to Deinococcus radiodurans shikimate 5-dehydrogenase, putative DR0077 TR:Q9RY73 (EMBL:AE001871) (273 aa) fasta scores: E(): 1.2e-48, 54.3% id in 267 aa, and to Haemophilus influenzae hypothetical shikimate 5-dehydrogenase-like protein Hi0607 hi0607 SW:YDIB_HAEIN (P44774) (271 aa) fasta scores: E(): 1.4e-45, 49.25% id in 268 aa, and to Escherichia coli hypothetical shikimate 5-dehydrogenase-like protein ydib ydib or B1692 SW:YDIB_ECOLI (P28244) (288 aa) fasta scores: E(): 1.9e-09, 30.03% id in 263 aa.
  
 0.857
DIP1790
Glutamine amidotransferase protein; N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa.
 
   
 0.806
DIP0707
Conserved hypothetical protein; Similar to Halobacterium sp VNG0686c TR:Q9HRI0 (EMBL:AE005014) (229 aa) fasta scores: E(): 4.5e-12, 35.51% id in 245 aa; Belongs to the SOS response-associated peptidase family.
     
 0.798
DIP0834
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 11.8 kDa protein Rv0948c or MT0975 or MTCY10D7.26 SW:Y948_MYCTU (P71562) (105 aa) fasta scores: E(): 1.6e-14, 62.35% id in 85 aa.
  
  
 0.770
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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