Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
DIP0722Similar to Streptomyces coelicolor putative ATP-dependent DNA helicase 2SC3B6.07 TR:Q9FCK5 (EMBL:AL390968) (1159 aa) fasta scores: E(): 6.2e-29, 32.21% id in 1161 aa; Belongs to the helicase family. UvrD subfamily. (1060 aa)    
Predicted Functional Partners:
DIP0723
Putative helicase; Similar to Mycobacterium tuberculosis CDC1551 helicase, UvrD/Rep family MT3295 TR:AAK47638 (EMBL:AE007142) (1101 aa) fasta scores: E(): 2.9e-25, 43.03% id in 1120 aa; Belongs to the helicase family. UvrD subfamily.
 
 
  0.996
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
 
 0.984
DIP0721
Similar to Mycobacterium leprae hypothetical protein ML0818 TR:Q9CCG7 (EMBL:AL583919) (297 aa) fasta scores: E(): 1.2e-34, 39.47% id in 266 aa.
       0.836
DIP0068
Hypothetical protein; Weak similarities to Streptomyces coelicolor putative DNA polymerase III, epsilon chain SCI8.12 TR:Q9RJ41 (EMBL:AL132644) (328 aa) fasta scores: E(): 2.7, 42.22% id in 45 aa, and to Thermotoga maritima DNA polymerase III PolC-type PolC or TM0576 SW:DPO3_THEMA (Q9ZHF6) (1367 aa) fasta scores: E(): 9.3, 39.58% id in 48 aa.
  
  
 0.809
DIP1573
Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit CAC0738 TR:AAK78714 (EMBL:AE007589) (306 aa) fasta scores: E(): 1.4e-14, 28.9% id in 339 aa, and to the exonuclease domain of Bacillus halodurans DNA polymerase III PolC-type PolC or BH2418 SW:DPO3_BACHD (Q9KA72) (1433 aa) fasta scores: E(): 2.7e-08, 28.62% id in 248 aa.
  
  
 0.809
DIP0719
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 hypothetical 10.1 kDa protein MT3304 TR:AAK47646 (EMBL:AE007142) (97 aa) fasta scores: E(): 4.5e-11, 51.38% id in 72 aa.
       0.785
DIP0720
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 31.0 kDa protein Rv3207c or MTCY07D11.19 TR:O05859 (EMBL:Z95120) (285 aa) fasta scores: E(): 1.7e-44, 46.69% id in 287 aa.
       0.785
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.771
radA
Conserved hypothetical protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.763
uvrC
Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
   
  
 0.753
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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