STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0725Putative hydrolase; Similar to C-terminal region of Vibrio cholerae NADH pyrophosphatase NudC or VC0331 SW:NUDC_VIBCH (Q9KV27) (269 aa) fasta scores: E(): 2.3e-11, 32.75% id in 174 aa. (227 aa)    
Predicted Functional Partners:
DIP1858
Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
    
 0.913
nadD
Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.902
nadE
NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
  
 
  0.902
nadC
Similar to Mycobacterium tuberculosis nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or Rv1596 or MT1632 or MTCY336.08c SWALL:NADC_MYCTU (SWALL:O06594) (285 aa) fasta scores: E(): 2.1e-43, 51.09% id in 274 aa, and to Salmonella typhimurium nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or STM0145 SWALL:NADC_SALTY (SWALL:P30012) (296 aa) fasta scores: E(): 1.6e-34, 41.17% id in 272 aa; Belongs to the NadC/ModD family.
     
 0.901
ppnK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
     
  0.900
DIP1457
Putative competence-damage related protein; Similar to Streptomyces coelicolor hypothetical 18.5 kDa protein Sc7C7.09 TR:O86814 (EMBL:AL031031) (181 aa) fasta scores: E(): 1.7e-13, 36.87% id in 160 aa, and to the C-terminal region of Streptococcus pneumoniae putative competence-damage protein CinA or Exp10 or SP1941 SW:CINA_STRPN (P54184) (418 aa) fasta scores: E(): 4.3e-15, 47.86% id in 117 aa.
     
  0.900
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
       0.817
DIP0724
Similar to Mycobacterium tuberculosis CDC1551 transporter, putative MT3294 TR:AAK47637 (EMBL:AE007142) (355 aa) fasta scores: E(): 2.5e-75, 61.78% id in 348 aa, and to Escherichia coli putative potassium channel protein Kch or B1250 SW:KCH_ECOLI (P31069) (417 aa) fasta scores: E(): 1.5e-07, 26.06% id in 234 aa.
       0.737
DIP0721
Similar to Mycobacterium leprae hypothetical protein ML0818 TR:Q9CCG7 (EMBL:AL583919) (297 aa) fasta scores: E(): 1.2e-34, 39.47% id in 266 aa.
  
    0.719
DIP0722
Similar to Streptomyces coelicolor putative ATP-dependent DNA helicase 2SC3B6.07 TR:Q9FCK5 (EMBL:AL390968) (1159 aa) fasta scores: E(): 6.2e-29, 32.21% id in 1161 aa; Belongs to the helicase family. UvrD subfamily.
       0.699
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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