STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrDPutative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa. (683 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 0.999
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.999
DIP0723
Putative helicase; Similar to Mycobacterium tuberculosis CDC1551 helicase, UvrD/Rep family MT3295 TR:AAK47638 (EMBL:AE007142) (1101 aa) fasta scores: E(): 2.9e-25, 43.03% id in 1120 aa; Belongs to the helicase family. UvrD subfamily.
 
0.998
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.998
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
 
 0.996
DIP1025
Putative exonuclease, SbcD-family; Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa.
  
 0.996
DIP0722
Similar to Streptomyces coelicolor putative ATP-dependent DNA helicase 2SC3B6.07 TR:Q9FCK5 (EMBL:AL390968) (1159 aa) fasta scores: E(): 6.2e-29, 32.21% id in 1161 aa; Belongs to the helicase family. UvrD subfamily.
 
 
 0.989
DIP1026
Similar to Mycobacterium leprae hypothetical protein ML1120 TR:Q9CC83 (EMBL:AL583920) (873 aa) fasta scores: E(): 1.9e-14, 28.49% id in 888 aa, and to Mycobacterium tuberculosis hypothetical 93.4 kDa protein Rv1278 or MT1315 or MTCY50.04c SW:YC78_MYCTU (Q11042) (875 aa) fasta scores: E(): 3.3e-13, 29% id in 893 aa. Contains coiled-coil domains, and thus some probably non-specific similarity to e.g. Drosophila melanogaster myosin heavy chain, non-muscle zip SW:MYSN_DROME (Q99323) (2017 aa) fasta scores: E(): 5.7e-07, 23.06% id in 568 aa.
  
 0.988
pcrA
Similar to Mycobacterium leprae ATP-dependent DNA helicase PcrA or UvrD or ML0153 SW:PCRA_MYCLE (Q9CD72) (778 aa) fasta scores: E(): 5.7e-165, 59.08% id in 804 aa, and to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 4.1e-80, 42.76% id in 802 aa.
 
0.973
DIP1023
SNF2/RAD54 family protein; Similar to Mycobacterium tuberculosis CDC1551 helicase, SNF2/RAD54 family MT2161 TR:AAK46443 (EMBL:AE007065) (954 aa) fasta scores: E(): 7.8e-94, 38.56% id in 1006 aa, and to Synechocystis sp helicase of the SNF2/RAD54 family SLL1366 TR:P74552 (EMBL:D90916) (1039 aa) fasta scores: E(): 1.9e-83, 34.17% id in 986 aa.
   
 
 0.959
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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