Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0786Putative FK506-binding protein; Similar to Corynebacterium glutamicum probable FK506-binding protein SW:FKBP_CORGL (P42458) (118 aa) fasta scores: E(): 8.4e-38, 82.05% id in 117 aa, and to Escherichia coli FkbP-type peptidyl-prolyl cis-trans isomerase FkpA precursor or B3347 SW:FKBA_ECOLI (P45523) (270 aa) fasta scores: E(): 2.3e-09, 42.71% id in 103 aa. (119 aa)    
Predicted Functional Partners:
infA
Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
   
   0.911
DIP0716
Putative secreted protein; Low similarity to Mycobacterium leprae putative membrane protein ML0810 TR:Q9CCH4 (EMBL:AL583919) (407 aa) fasta scores: E(): 1.1e-21, 26.81% id in 414 aa.
   
 
 0.717
lysC
Aspartokinase; Similar to Corynebacterium flavum aspartokinase LysC or Ask SW:AK_CORFL (P41398) (421 aa) fasta scores: E(): 1.8e-135, 87.64% id in 421 aa; Belongs to the aspartokinase family.
    
   0.712
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.670
DIP1321
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 48.5 kDa protein Rv1407 or MT1451 or MTCY21B4.24 SWALL:YE07_MYCTU (SWALL:P71675) (457 aa) fasta scores: E(): 6.2e-86, 55.4% id in 453 aa, and to Escherichia coli Sun protein Sun or Fmu or Fmv or RsmB or B3289 SWALL:SUN_ECOLI (SWALL:P36929) (429 aa) fasta scores: E(): 1.2e-31, 33.63% id in 449 aa; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
   0.630
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
       0.627
DIP1768
Conserved hypothetical protein; Similar to Streptomyces coelicolor putative ankyrin-like protein SC6D7.25 TR:Q9RKX3 (EMBL:AL133213) (134 aa) fasta scores: E(): 4.4e-23, 57.36% id in 129 aa, and to Campylobacter jejuni ankyrin-repeat containing protein Cj1386 TR:Q9PMR4 (EMBL:AL139078) (156 aa) fasta scores: E(): 1.2e-10, 39.66% id in 121 aa.
    
 0.595
rplW
50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family.
   
 
 0.592
rplR
50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
   
   0.574
rplE
50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
   
   0.521
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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