STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0786Putative FK506-binding protein; Similar to Corynebacterium glutamicum probable FK506-binding protein SW:FKBP_CORGL (P42458) (118 aa) fasta scores: E(): 8.4e-38, 82.05% id in 117 aa, and to Escherichia coli FkbP-type peptidyl-prolyl cis-trans isomerase FkpA precursor or B3347 SW:FKBA_ECOLI (P45523) (270 aa) fasta scores: E(): 2.3e-09, 42.71% id in 103 aa. (119 aa)    
Predicted Functional Partners:
infA
Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
   
   0.923
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.811
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 
   0.651
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
       0.645
DIP0604
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 56.7 kDa protein Rv3394c or MTV004.52c TR:O50419 (EMBL:AL009198) (527 aa) fasta scores: E(): 2e-34, 32.63% id in 527 aa.
    
   0.606
lysC
Aspartokinase; Similar to Corynebacterium flavum aspartokinase LysC or Ask SW:AK_CORFL (P41398) (421 aa) fasta scores: E(): 1.8e-135, 87.64% id in 421 aa; Belongs to the aspartokinase family.
    
   0.600
tgt
Putative tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form [...]
    
  0.497
DIP0064
Putative two-component system response regulator; Similar to Enterococcus faecalis VicR protein TR:Q9REA7 (EMBL:AJ012050) (283 aa) fasta scores: E(): 5.5e-35, 44.978% id in 229 aa, to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 3e-34, 42.918% id in 233 aa, and to Bacillus subtilis hypothetical sensory transduction protein YycF SW:YYCF_BACSU (P37478) (235 aa) fasta scores: E(): 1.8e-33, 43.478% id in 230 aa.
      
 0.487
rbfA
Putative ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
      
 0.480
DIP1321
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 48.5 kDa protein Rv1407 or MT1451 or MTCY21B4.24 SWALL:YE07_MYCTU (SWALL:P71675) (457 aa) fasta scores: E(): 6.2e-86, 55.4% id in 453 aa, and to Escherichia coli Sun protein Sun or Fmu or Fmv or RsmB or B3289 SWALL:SUN_ECOLI (SWALL:P36929) (429 aa) fasta scores: E(): 1.2e-31, 33.63% id in 449 aa; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
   0.475
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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