STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
DIP0824Putative folate reductase; Similar to Mycobacterium avium dihydrofolate reductase FolA TR:O30463 (EMBL:AF006616) (181 aa) fasta scores: E(): 2e-22, 46.1% id in 167 aa, and to Escherichia coli dihydrofolate reductase FolA or TmrA or B0048 SW:DYR_ECOLI (P00379) (159 aa) fasta scores: E(): 1.5e-13, 42.76% id in 152 aa. (167 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.999
thyX
Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.988
DIP1785
Mur ligase family protein; Similar to Mycobacterium tuberculosis folylpolyglutamate synthase Rv2447c TR:O53174 (EMBL:AL021246) (487 aa) fasta scores: E(): 1.2e-100, 57.46% id in 496 aa, and to Mycobacterium leprae folylpolyglutamate synthase ML1471 TR:Q9CBY8 (EMBL:AL583922) (485 aa) fasta scores: E(): 3.8e-96, 56.17% id in 470 aa.
     
 0.957
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.931
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.922
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.922
fhs
Formyltetrahydrofolate synthetase; Similar to Staphylococcus aureus (strain N315) formyltetrahydrofolate synthetase Fhs or SA1553 or SAV1732 SWALL:Q99TD2 (EMBL:AP003134) (555 aa) fasta scores: E(): 1.2e-125, 59.34% id in 551 aa, and to Moorella thermoacetica formate--tetrahydrofolate ligase Fhs SWALL:FTHS_MOOTH (SWALL:P21164) (559 aa) fasta scores: E(): 4.9e-116, 55.57% id in 556 aa.
  
 
 0.920
purN
5'-phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.916
purH
Similar to Mycobacterium tuberculosis bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydorlase (EC 3.5.4.10)] or Rv0957 or MT0984 or MTCY10D7.17c SW:PUR9_MYCTU (P71553) (523 aa) fasta scores: E(): 1e-137, 68.06% id in 526 aa, and to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydrolase (EC 3.5.4.10)] PurH or B4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1e-58, 45.25% id in 537 aa.
    
 0.914
DIP2057
Putative phosphoribosylglycinamide formyltransferase; Similar to although shorter in its N-terminal region than Pasteurella haemolytica probable phosphoribosylglycinamide formyltransferase 2 PurT or Mpa1 SWALL:PURT_PASHA (SWALL:P46927) (392 aa) fasta scores: E(): 1e-12, 32.24% id in 276 aa, than Bacillus subtilis phosphoribosylglycinamide formyltransferase 2 PurT SWALL:PURT_BACSU (SWALL:P39771) (384 aa) fasta scores: E(): 3.8e-12, 35.81% id in 282 aa, and than Escherichia coli phosphoribosylglycinamide formyltransferase 2 PurT or B1849 SWALL:PURT_ECOLI (SWALL:P33221) (391 aa) fasta sco [...]
     
  0.900
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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