STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0834Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 11.8 kDa protein Rv0948c or MT0975 or MTCY10D7.26 SW:Y948_MYCTU (P71562) (105 aa) fasta scores: E(): 1.6e-14, 62.35% id in 85 aa. (110 aa)    
Predicted Functional Partners:
aroH
Similar to Streptomyces coelicolor phospho-2-dehydro-3-deoxyheptonate aldolase AroH or SC6E10.09c SW:AROF_STRCO (P80574) (449 aa) fasta scores: E(): 2.4e-92, 55.6% id in 437 aa, and to Mycobacterium tuberculosis CDC1551 phospho-2-dehydro-3-deoxyheptonate aldolase, putative MT2234 TR:AAK46519 (EMBL:AE007070) (462 aa) fasta scores: E(): 2.9e-129, 67.53% id in 462 aa; Belongs to the class-II DAHP synthase family.
   
 
 0.999
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.970
trpG
Similar to Corynebacterium glutamicum anthranilate synthase component II TrpG SW:TRPG_CORGL (P06558) (208 aa) fasta scores: E(): 5.8e-52, 65.23% id in 210 aa.
  
 
 0.951
DIP0245
Putative prephenate dehydrogenase; Similar to Mycobacterium tuberculosis CDC1551 prephenate dehydrogenase MT3861 TR:AAK48225 (EMBL:AE007181) (323 aa) fasta scores: E(): 5.5e-49, 52.31% id in 281 aa, and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) (372 aa) fasta scores: E(): 2.7e-15, 31.9% id in 279 aa.
 
 0.948
DIP1790
Glutamine amidotransferase protein; N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa.
  
 
 0.946
trpE
Similar to Corynebacterium glutamicum anthranilate synthase component I TrpE SW:TRPE_CORGL (P06557) (518 aa) fasta scores: E(): 5.7e-128, 65.44% id in 518 aa, and to Escherichia coli anthranilate synthase component I trpE or b1264 SW:TRPE_ECOLI (P00895) (520 aa) fasta scores: E(): 6.3e-66, 47.44% id in 508 aa.
  
 
 0.929
pheA
Prephenate dehydratase; Similar to Corynebacterium glutamicum prephenate dehydratase PheA SW:PHEA_CORGL (P10341) (315 aa) fasta scores: E(): 8.6e-50, 52.75% id in 290 aa, and to Streptomyces coelicolor prephenate dehydratase SCD78.29c TR:Q9ZBX0 (EMBL:AL034355) (310 aa) fasta scores: E(): 6.4e-31, 39.63% id in 270 aa.
  
 
 0.926
DIP1114
Similar to Bacillus subtilis isochorismate synthase DhbC SW:DHBC_BACSU (P45744) (398 aa) fasta scores: E(): 1.9e-43, 41.01% id in 356 aa, and to Stigmatella aurantiaca MxcD TR:Q9F639 (EMBL:AF299336) (408 aa) fasta scores: E(): 7e-40, 36.91% id in 382 aa, and to Vibrio cholerae vibriobactin-specific isochorismate synthase VibC or VC0773 SW:VIBC_VIBCH (O07898) (395 aa) fasta scores: E(): 2.8e-31, 35.45% id in 330 aa.
  
 
 0.871
DIP1617
Conserved hypothetical protein; Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
  
     0.773
DIP1455
Conserved hypothetical protein; Similar in its full length to Mycobacterium tuberculosis 35 kDa protein Rv2744c or MT2815 or MTV002.09c SW:35KD_MYCTU (P31511) (270 aa) fasta scores: E(): 1.2e-51, 75.8% id in 248 aa, N-terminal region to Mycobacterium leprae B2235_C2_187 MLCB33.06c TR:Q49840 (EMBL:U00019) (167 aa) fasta scores: E(): 2.9e-27, 72.1% id in 147 aa, and C-terminal region to Mycobacterium leprae B2235_C3_214 MLCB33.05c TR:Q49845 (EMBL:U00019) (114 aa) fasta scores: E(): 3.4e-12, 58.18% id in 110 aa.
  
     0.771
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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