STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pcrASimilar to Mycobacterium leprae ATP-dependent DNA helicase PcrA or UvrD or ML0153 SW:PCRA_MYCLE (Q9CD72) (778 aa) fasta scores: E(): 5.7e-165, 59.08% id in 804 aa, and to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 4.1e-80, 42.76% id in 802 aa. (805 aa)    
Predicted Functional Partners:
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
 
0.973
DIP0723
Putative helicase; Similar to Mycobacterium tuberculosis CDC1551 helicase, UvrD/Rep family MT3295 TR:AAK47638 (EMBL:AE007142) (1101 aa) fasta scores: E(): 2.9e-25, 43.03% id in 1120 aa; Belongs to the helicase family. UvrD subfamily.
 
 
 
0.953
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
  
 
 0.942
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.845
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 
 0.781
uvrC
Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.780
DIP0834
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 11.8 kDa protein Rv0948c or MT0975 or MTCY10D7.26 SW:Y948_MYCTU (P71562) (105 aa) fasta scores: E(): 1.6e-14, 62.35% id in 85 aa.
       0.684
lexA
Transcriptional repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
   
 0.653
DIP0068
Hypothetical protein; Weak similarities to Streptomyces coelicolor putative DNA polymerase III, epsilon chain SCI8.12 TR:Q9RJ41 (EMBL:AL132644) (328 aa) fasta scores: E(): 2.7, 42.22% id in 45 aa, and to Thermotoga maritima DNA polymerase III PolC-type PolC or TM0576 SW:DPO3_THEMA (Q9ZHF6) (1367 aa) fasta scores: E(): 9.3, 39.58% id in 48 aa.
  
  
 0.616
DIP1573
Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit CAC0738 TR:AAK78714 (EMBL:AE007589) (306 aa) fasta scores: E(): 1.4e-14, 28.9% id in 339 aa, and to the exonuclease domain of Bacillus halodurans DNA polymerase III PolC-type PolC or BH2418 SW:DPO3_BACHD (Q9KA72) (1433 aa) fasta scores: E(): 2.7e-08, 28.62% id in 248 aa.
  
  
 0.616
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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