STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
uppS1Putative undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (265 aa)    
Predicted Functional Partners:
DIP1612
Similar to Mycobacterium aurum geranylgeranyl pyrophosphate synthase GgpP TR:Q9K567 (EMBL:AJ133724) (371 aa) fasta scores: E(): 1.5e-36, 39.09% id in 353 aa, and to Sulfolobus acidocaldarius geranylgeranyl pyrophosphate synthetase Gds SW:GGPP_SULAC (P39464) (330 aa) fasta scores: E(): 3.1e-11, 28.49% id in 358 aa.
 
 
 0.972
idi
Isopentenyl-diphosphate delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 
 0.908
lytB
Putative penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
     
 0.907
DIP1504
Putative phospholipid biosynthesis; Similar to Mycobacterium tuberculosis phosphatidate cytidylyltransferase CdsA or Rv2881c or MT2948 or MTCY274.12c SW:CDSA_MYCTU (Q10807) (306 aa) fasta scores: E(): 2.4e-51, 51.73% id in 288 aa, and to Escherichia coli phosphatidate cytidylyltransferase CdsA or Cds or B0175 or Z0186 or ECS0177 SW:CDSA_ECOLI (P06466) (249 aa) fasta scores: E(): 1.9e-14, 35.35% id in 198 aa; Belongs to the CDS family.
  
  
 0.783
DIP0928
Putative membrane protein; No significant database matches.
       0.782
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
  
  
 0.778
DIP0930
Hypothetical protein; No significant database matches.
  
   0.757
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
  
  
 0.745
DIP0429
Similar to Mycobacterium leprae polyprenyl diphosphate synthase component ML2277 TR:Q9CBA5 (EMBL:AL583925) (330 aa) fasta scores: E(): 1.6e-57, 51.69% id in 325 aa, and to Bacillus stearothermophilus heptaprenyl diphosphate synthase component II HepT or HepS-2 SW:HEP2_BACST (P55785) (320 aa) fasta scores: E(): 9.6e-33, 38.99% id in 318 aa.
 
  
 0.737
nusA
Putative N utilization related protein; Participates in both transcription termination and antitermination.
  
    0.719
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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