STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)    
Predicted Functional Partners:
mqo
Putative magnesium chelatase (pseudogene); HMMSmart hit to SM00382, ATPases associated with a variety of cellular activities.
    
 0.986
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
  
 0.983
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.982
DIP0371
Similar to Bacillus subtilis succinate dehydrogenase flavoprotein subunit SdhA or CitF SWALL:DHSA_BACSU (SWALL:P08065) (585 aa) fasta scores: E(): 5.8e-26, 34.71% id in 579 aa, and to Escherichia coli fumarate reductase flavoprotein subunit FrdA or B4154 SWALL:FRDA_ECOLI (SWALL:P00363) (601 aa) fasta scores: E(): 5.7e-18, 31.72% id in 580 aa.
 
 0.979
DIP0372
Similar to Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB SWALL:DHSB_BACSU (SWALL:P08066) (252 aa) fasta scores: E(): 1.3e-08, 27.45% id in 255 aa, and to Escherichia coli succinate dehydrogenase iron-sulfur protein SdhB or B0724 SWALL:DHSB_ECOLI (SWALL:P07014) (238 aa) fasta scores: E(): 6.8e-08, 29.43% id in 248 aa.
  
 0.954
cat1
Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 1.8e-85, 47.56% id in 513 aa, and to Caulobacter crescentus coenzyme A transferase, putative CC3724 SWALL:Q9A242 (EMBL:AE006030) (514 aa) fasta scores: E(): 1.3e-97, 52.96% id in 506 aa.
  
  
 0.922
DIP0370
Low similarity to Bacillus pseudofirmus succinate dehydrogenease cytochrome B-558 subunit DhsC SWALL:O54447 (EMBL:U91843) (159 aa) fasta scores: E(): 0.011, 28.22% id in 163 aa, and to Streptomyces coelicolor putative cytochrome B subunit SCM10.12c TR:Q9RCY6 (EMBL:AL133469) (243 aa) fasta scores: E(): 1.8e-18, 36.01% id in 236 aa.
     
  0.900
DIP2331
Putative aldehyde dehydrogenase; Similar to Deinococcus radiodurans succinate-semialdehyde dehydrogenase [NADP+] SsdA or DRA0343 SWALL:GABD_DEIRA (SWALL:O32507) (477 aa) fasta scores: E(): 1.2e-81, 49.44% id in 453 aa, and to Streptomyces coelicolor putative aldehyde dehydrogenase 2SCG58.04 SWALL:Q9FCA9 (EMBL:AL391017) (461 aa) fasta scores: E(): 4.1e-65, 42.57% id in 458 aa, and to Ustilago maydis indole-3-acetaldehyde dehydrogenase Iad1 SWALL:Q92460 (EMBL:U74468) (497 aa) fasta scores: E(): 1.6e-48, 37.04% id in 467 aa.
    
 0.884
DIP0833
Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or B2661 SW:GABD_ECOLI (P25526) (482 aa) fasta scores: E(): 2.9e-76, 44.37% id in 471 aa.
    
 0.841
DIP2136
Putative aminotransferase; Similar to Mycobacterium tuberculosis probable aspartate aminotransferase AspC or Rv0337c or MT0351 or MTCY279.04c SW:AAT_MYCTU (O33267) (429 aa) fasta scores: E(): 2.4e-120, 71.32% id in 415 aa, and to Escherichia coli probable aminotransferase YfbQ or B2290 SW:YFBQ_ECOLI (P77727) (405 aa) fasta scores: E(): 1.8e-101, 61.59% id in 401 aa, and to Methylobacillus flagellatum aspartate aminotransferase Aat TR:Q9RAN0 (EMBL:L78665) (429 aa) fasta scores: E(): 1.7e-87, 55.08% id in 403 aa.
    
 0.815
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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