Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (85 aa)    
Predicted Functional Partners:
xseA
Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.
 
 0.999
DIP1798
Putative aminopeptidase; Similar to Streptomyces lividans aminopeptidase N PepN SW:AMPN_STRLI (Q11010) (857 aa) fasta scores: E(): 1.2e-88, 45.27% id in 888 aa, and to Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa) fasta scores: E(): 1.9e-132, 51.97% id in 885 aa. CDS appears to be extended at the N-terminus in comparison to orthologues. Possible alternative translational start site, although current start has better RBS and extented region contains Pfam hit.
  
   
 0.856
lytB
Putative penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
     
 0.673
rsmI
Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
   
  
 0.638
DIP1402
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2773 TR:AAK47088 (EMBL:AE007106) (100 aa) fasta scores: E(): 1.6e-17, 57% id in 100 aa, and to Streptomyces coelicolor hypothetical 11.0 kDa protein SC2E9.05 TR:O54130 (EMBL:AL021530) (98 aa) fasta scores: E(): 4.9e-14, 49.49% id in 99 aa.
  
     0.549
DIP0729
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 49.4 kDa protein Rv3195 or MTV014.39 TR:O53341 (EMBL:AL021646) (472 aa) fasta scores: E(): 5.1e-65, 45.37% id in 432 aa.
  
     0.534
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
  
  
 0.533
DIP1456
Putative DNA-binding protein; Similar to Mycobacterium tuberculosis CDC1551 DNA-binding protein, putative MT2816 TR:AAK47136 (EMBL:AE007109) (112 aa) fasta scores: E(): 1.2e-09, 56.16% id in 73 aa, and to Streptomyces coelicolor hypothetical 13.6 kDa protein SC7C7.10 TR:O86815 (EMBL:AL031031) (126 aa) fasta scores: E(): 1.1e-08, 49.39% id in 83 aa.
  
     0.511
rbpA
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.
  
     0.503
DIP1025
Putative exonuclease, SbcD-family; Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa.
      
 0.495
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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