STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0974Putative aminotransferase; Similar to Mycobacterium leprae possible aminotransferase ML1488 TR:Q9CBX8 (EMBL:AL583922) (367 aa) fasta scores: E(): 3.9e-81, 60.44% id in 364 aa. Possible alternative transcription start in the second residue. (366 aa)    
Predicted Functional Partners:
dapE
Similar to Corynebacterium glutamicum succinyl-diaminopimelate desuccinylase DapE SW:DAPE_CORGL (Q59284) (369 aa) fasta scores: E(): 1.2e-87, 61.11% id in 360 aa, and to Escherichia coli succinyl-diaminopimelate desuccinylase DapE or MsgB or B2472 SW:DAPE_ECOLI (P24176) (375 aa) fasta scores: E(): 3.8e-09, 28.53% id in 354 aa.
 
  
 0.963
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
 
 
 0.939
fdxA
Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
    
 0.933
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
  
 0.788
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
 
   
 0.774
DIP0975
Similar to, although shorter than, Mycobacterium tuberculosis CDC1551 RNA pseudouridylate synthase family protein MT3399 TR:AAK47742 (EMBL:AE007148) (305 aa) fasta scores: E(): 3.5e-23, 37.33% id in 233 aa, and similar to Escherichia coli ribosomal large subunit pseudouridine synthase A RluR or B0058 SW:RLUA_ECOLI (P39219) (218 aa) fasta scores: E(): 1.8e-07, 26.76% id in 213 aa.
       0.747
dapD
Putative succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
 
  
 0.745
DIP0981
Putative succinyltransferase; Similar to Mycobacterium tuberculosis CDC1551 tetrahydrodipicolinate N-succinyltransferase, putative MT1239 TR:AAK45496 (EMBL:AE007001) (317 aa) fasta scores: E(): 3.2e-46, 46.53% id in 303 aa, and C-terminal region to Corynebacterium glutamicum tetrahydrodipicolinate succinylase DapD TR:O69283 (EMBL:AJ004934) (230 aa) fasta scores: E(): 1.6e-28, 45.2% id in 219 aa. Similar also to DIP0979 (45.614% identity in 285 aa overlap).
 
  
 0.737
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.700
DIP0972
Putative membrane protein; No significant database matches.
       0.695
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (64%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.