STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0994Similar to Mycobacterium avium putative RNA polymerase sigma factor SigE TR:O05735 (EMBL:U87308) (251 aa) fasta scores: E(): 1.2e-47, 62.33% id in 223 aa, and to Bacillus subtilis RNA polymerase sigma factor SigW SW:SIGW_BACSU (Q45585) (187 aa) fasta scores: E(): 4.2e-13, 32.36% id in 173 aa; Belongs to the sigma-70 factor family. ECF subfamily. (239 aa)    
Predicted Functional Partners:
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.866
rpoC
DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.866
DIP1974
Putative CarD-like transcriptional factor; N-terminal region is similar to Mycobacterium tuberculosis putative transcriptional factor Rv3583c TR:O53568 (EMBL:AL022075) (162 aa) fasta scores: E(): 6.8e-38, 71.69% id in 159 aa, and to Mycobacterium leprae putative transcription factor ML0320 TR:Q9CCW7 (EMBL:AL583918) (165 aa) fasta scores: E(): 1.2e-37, 70.44% id in 159 aa.
    
   0.866
DIP0995
Similar to Mycobacterium leprae hypothetical protein ML1077 TR:Q9CCA5 (EMBL:AL583920) (139 aa) fasta scores: E(): 8e-09, 40.35% id in 114 aa.
  
   0.822
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.748
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 
 0.713
DIP1735
Putative ABC transport system ATP-binding membrane protein; Similar to Amycolatopsis orientalis hypothetical 71.1 kDa protein PCZA363.2 CZA382.30 TR:O52818 (EMBL:AJ223999) (650 aa) fasta scores: E(): 1.8e-39, 30.58% id in 618 aa.
      
 0.697
tatB
Putative Sec-independent twin-arginine translocase system protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
       0.692
DIP0993
Putative methyltransferase; Similar to Mycobacterium tuberculosis CDC1551 O-methyltransferase MT1258 TR:AAK45515 (EMBL:AE007002) (215 aa) fasta scores: E(): 6e-17, 37.91% id in 182 aa.
       0.686
DIP0880
Similar to Xanthomonas campestris probable RNA polymerase sigma factor RfaY SW:RFAY_XANCP (P46358) (217 aa) fasta scores: E(): 9.8e-07, 32.88% id in 149 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.677
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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