STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
odhA2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...] (1243 aa)    
Predicted Functional Partners:
lpd
Similar to Corynebacterium glutamicum dihydrolipoamide dehydrogenase Lpd TR:Q9Z466 (EMBL:Y16642) (469 aa) fasta scores: E(): 1.1e-135, 78.03% id in 469 aa, and to Zymomonas mobilis dihydrolipoamide dehydrogenase Lpd SW:DLDH_ZYMMO (P50970) (466 aa) fasta scores: E(): 5.7e-66, 43.55% id in 473 aa.
 
 0.999
lpdA
Similar to Mycobacterium tuberculosis dihydrolipoamide dehydrogenase LpdA or Rv3303c or MTV016.02c TR:O53355 (EMBL:AL021841) (493 aa) fasta scores: E(): 5.8e-110, 64.04% id in 470 aa, and to Bacillus subtilis dihydrolipoamide dehydrogenase PdhD or AceD or CitL SW:DLD1_BACSU (P21880) (470 aa) fasta scores: E(): 1.2e-36, 31.47% id in 467 aa.
  
 0.999
odhI
Putative signal transduction protein; An essential component of the PknG signaling pathway. When unphosphorylated, it inhibits the activity of 2-oxoglutarate dehydrogenase. When phosphorylated it does not inhibit 2-oxoglutarate dehydrogenase (By similarity).
    
 
 0.999
DIP1494
Similar to Mycobacterium tuberculosis glutathione reductase homolog GorA or Rv2855 or MTCY24A1.02c TR:O07927 (EMBL:AF002193) (459 aa) fasta scores: E(): 4.1e-91, 56.18% id in 461 aa, and to Staphylococcus aureus mercuric reductase MerA SW:MERA_STAAU (P08663) (547 aa) fasta scores: E(): 4.7e-36, 30.17% id in 464 aa.
  
 0.999
pdhC
Similar to Acholeplasma laidlawii dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_ACHLA (P35489) (544 aa) fasta scores: E(): 8.7e-49, 37.7% id in 541 aa, to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB or Rv2215 or MT2272 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 8.9e-95, 58.49% id in 559 aa, and to Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_BACST (P11961) (427 aa) fasta [...]
 
0.998
DIP0058
Putative secreted protein; Similar to Mycobacterium leprae hypothetical 17.2 kDa protein MLB1770.14c or ML0021 TR:Q50189 (EMBL:Z70722) (155 aa) fasta scores: E(): 2.3e-13, 35% id in 160 aa.
    
 
 0.994
DIP0059
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 30.8 kDa protein SCH69.13 TR:Q9XA21 (EMBL:AL079308) (290 aa) fasta scores: E(): 3.1e-11, 27.6% id in 297 aa.
    
 
 0.994
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.987
atpA
ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
  
 
 0.985
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
 
 
 0.977
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.