STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
galKGalactokinase; Similar to Streptomyces lividans galactokinase GalK SW:GAL1_STRLI (P13227) (397 aa) fasta scores: E(): 1.3e-27, 36.45% id in 384 aa, and to Homo sapiens galactokinase GalK1 or GalK SW:GAL1_HUMAN (P51570) (392 aa) fasta scores: E(): 3e-23, 38.29% id in 410 aa, and to Escherichia coli galactokinase GalK or GalA or B0757 or Z0927 or ECS0785 SW:GAL1_ECOLI (P06976) (381 aa) fasta scores: E(): 1e-11, 32.08% id in 399 aa; Belongs to the GHMP kinase family. GalK subfamily. (409 aa)    
Predicted Functional Partners:
galT
Similar to Escherichia coli galactose-1-phosphate uridylyltransferase GalT or GalB or B0758 SW:GAL7_ECOLI (P09148) (348 aa) fasta scores: E(): 1.2e-24, 30.34% id in 346 aa, and to Streptomyces lividans galactose-1-phosphate uridylyltransferase GalT SW:GAL7_STRLI (P13212) (354 aa) fasta scores: E(): 4.9e-30, 38.8% id in 384 aa, and to Homo sapiens galactose-1-phosphate uridylyltransferase GalT SW:GAL7_HUMAN (P07902) (379 aa) fasta scores: E(): 8.1e-29, 33.82% id in 340 aa.
 0.999
DIP1011
Similar to putative aldose 1-epimerases e.g. Escherichia coli O157:H7 putative aldose-1-epimerase ECS4802 TR:BAB38225 (EMBL:AP002567) (300 aa) fasta scores: E(): 3.1e-21, 29.09% id in 299 aa, and to Escherichia coli hypothetical protein YihR or B3879 SW:YIHR_ECOLI (P32139) (308 aa) fasta scores: E(): 7.7e-21, 30.35% id in 280 aa, and to Salmonella typhimurium putative aldose-1-epimerase YihR TR:Q9L7R7 (EMBL:AF220438) (280 aa) fasta scores: E(): 1.1e-13, 29.53% id in 281 aa. Contains weak match to PFAM:PF01263 Aldose 1-epimerase E: 0.089.
 
 0.988
galE
UDP-glucose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
 
 
 0.953
DIP1674
Hypothetical protein; Very low similarity to Homo sapiens galactokinase GalK1 or GalK SW:GAL1_HUMAN (P51570) blast scores: E(): 3e-05, score: 51 24% id.
     
  0.900
DIP1012
Similar to Streptomyces coelicolor putative sodium:solute symporter SCE66.18 TR:Q9K3S5 (EMBL:AL359989) (562 aa) fasta scores: E(): 7e-115, 56.42% id in 553 aa, and to Rattus norvegicus sodium-dependent multivitamin transporter slc5a6 or smvT SW:SL56_RAT (O70247) (634 aa) fasta scores: E(): 3.3e-23, 24.2% id in 504 aa; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
 
     0.810
DIP1013
Putative membrane protein; Similar to Streptomyces coelicolor putative membrane protein SCE66.19 TR:Q9K3S4 (EMBL:AL359989) (98 aa) fasta scores: E(): 6.7e-06, 46.15% id in 65 aa.
       0.799
DIP1550
Hypothetical protein; No significant database matches.
  
 
 0.757
rpsJ
30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
      
 0.624
ppnK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
   
  
 0.622
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
   
  
 0.611
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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