Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP1016Putative helicase; Similar to Streptomyces coelicolor putative helicase SCE20.37 TR:Q9RD88 (EMBL:AL136058) (945 aa) fasta scores: E(): 5.3e-162, 46.4% id in 933 aa, and to Vibrio cholerae helicase-related protein VC0812 TR:Q9KTS6 (EMBL:AE004166) (979 aa) fasta scores: E(): 3.5e-48, 31.6% id in 674 aa. (1043 aa)    
Predicted Functional Partners:
DIP1017
Putative NUDIX-family hydrolase; Similar to Staphylococcus aureus (strain N315) SA2278 or SAV2490 TR:BAB58652 (EMBL:AP003137) (130 aa) fasta scores: E(): 1e-24, 56.91% id in 123 aa, and to Escherichia coli CTP pyrophosphohydrolase NudG or B1759 SW:NUDG_ECOLI (P77788) (135 aa) fasta scores: E(): 3.3e-13, 41.4% id in 128 aa.
 
     0.897
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.657
DIP1859
DeaD/DeaH family helicase; Similar to Escherichia coli probable ATP-dependent helicase DinG SW:DING_ECOLI (P27296) (716 aa) fasta scores: E(): 5.6e-15, 27.57% id in 689 aa, and to Mycobacterium tuberculosis probable ATP-dependent helicase DinG homologue Rv1329c SW:DING_MYCTU (Q10640) (664 aa) fasta scores: E(): 2.2e-131, 55.84% id in 659 aa.
   
 0.551
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  0.516
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
  0.509
deaD
DEAD-box helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.
       0.503
DIP0115
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 39.2 kDa protein SCH24.21c TR:Q9X8T5 (EMBL:AL049826) (360 aa) fasta scores: E(): 5e-111, 79.49% id in 356 aa.
    
   0.414
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
  0.400
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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