STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1023SNF2/RAD54 family protein; Similar to Mycobacterium tuberculosis CDC1551 helicase, SNF2/RAD54 family MT2161 TR:AAK46443 (EMBL:AE007065) (954 aa) fasta scores: E(): 7.8e-94, 38.56% id in 1006 aa, and to Synechocystis sp helicase of the SNF2/RAD54 family SLL1366 TR:P74552 (EMBL:D90916) (1039 aa) fasta scores: E(): 1.9e-83, 34.17% id in 986 aa. (1029 aa)    
Predicted Functional Partners:
DIP1024
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 59.8 kDa protein orfZ TR:O86854 (EMBL:AJ007731) (566 aa) fasta scores: E(): 1.2e-07, 31.21% id in 189 aa, and to Sulfolobus solfataricus hypothetical protein Sso1656 sso1656 TR:Q97XQ4 (EMBL:AE006779) (217 aa) fasta scores: E(): 1.1e-06, 25.11% id in 211 aa.
 
    0.963
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
   
 
 0.959
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.891
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 0.870
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.867
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.860
DIP1025
Putative exonuclease, SbcD-family; Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa.
  
 
 0.857
DIP1026
Similar to Mycobacterium leprae hypothetical protein ML1120 TR:Q9CC83 (EMBL:AL583920) (873 aa) fasta scores: E(): 1.9e-14, 28.49% id in 888 aa, and to Mycobacterium tuberculosis hypothetical 93.4 kDa protein Rv1278 or MT1315 or MTCY50.04c SW:YC78_MYCTU (Q11042) (875 aa) fasta scores: E(): 3.3e-13, 29% id in 893 aa. Contains coiled-coil domains, and thus some probably non-specific similarity to e.g. Drosophila melanogaster myosin heavy chain, non-muscle zip SW:MYSN_DROME (Q99323) (2017 aa) fasta scores: E(): 5.7e-07, 23.06% id in 568 aa.
  
 
 0.847
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 0.764
rpoC
DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  0.752
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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