STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1026Similar to Mycobacterium leprae hypothetical protein ML1120 TR:Q9CC83 (EMBL:AL583920) (873 aa) fasta scores: E(): 1.9e-14, 28.49% id in 888 aa, and to Mycobacterium tuberculosis hypothetical 93.4 kDa protein Rv1278 or MT1315 or MTCY50.04c SW:YC78_MYCTU (Q11042) (875 aa) fasta scores: E(): 3.3e-13, 29% id in 893 aa. Contains coiled-coil domains, and thus some probably non-specific similarity to e.g. Drosophila melanogaster myosin heavy chain, non-muscle zip SW:MYSN_DROME (Q99323) (2017 aa) fasta scores: E(): 5.7e-07, 23.06% id in 568 aa. (854 aa)    
Predicted Functional Partners:
DIP1025
Putative exonuclease, SbcD-family; Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa.
 
 0.999
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
  
 0.988
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.971
DIP1023
SNF2/RAD54 family protein; Similar to Mycobacterium tuberculosis CDC1551 helicase, SNF2/RAD54 family MT2161 TR:AAK46443 (EMBL:AE007065) (954 aa) fasta scores: E(): 7.8e-94, 38.56% id in 1006 aa, and to Synechocystis sp helicase of the SNF2/RAD54 family SLL1366 TR:P74552 (EMBL:D90916) (1039 aa) fasta scores: E(): 1.9e-83, 34.17% id in 986 aa.
  
 
 0.847
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.842
DIP1024
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 59.8 kDa protein orfZ TR:O86854 (EMBL:AJ007731) (566 aa) fasta scores: E(): 1.2e-07, 31.21% id in 189 aa, and to Sulfolobus solfataricus hypothetical protein Sso1656 sso1656 TR:Q97XQ4 (EMBL:AE006779) (217 aa) fasta scores: E(): 1.1e-06, 25.11% id in 211 aa.
       0.775
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.689
arc
Putative AAA protein family ATPase; Similar to, although shorter in its N-terminal region than Streptomyces coelicolor AAA protein family ATPase Arc SWALL:Q9RJ58 (EMBL:AL132648) (588 aa) fasta scores: E(): 3e-76, 54.14% id in 519 aa, and to, although shorter in its N-terminal region than Mycobacterium leprae putative AAA-family ATPase ML1316 or MLCB2533.12 or A2126A or B2126_C1_167 SWALL:YL15_MYCLE (SWALL:P46509) (609 aa) fasta scores: E(): 2.1e-58, 54.99% id in 531 aa.
    
   0.652
putP
Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
       0.615
DIP1021
Putative exported protein; Similar to Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv2972c or MTCY349.15 TR:P95123 (EMBL:Z83018) (237 aa) fasta scores: E(): 1.3e-16, 34.7% id in 170 aa, and to Streptomyces coelicolor putative secreted protein scp1.323c or scp1.31 TR:Q99QB5 (EMBL:AL590464) (219 aa) fasta scores: E(): 2.2e-13, 35.18% id in 162 aa.
       0.579
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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