Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP1064Putative thioredoxin-like protein; Similar to Mycobacterium leprae TrxA SWALL:Q49716 (EMBL:U00014) (255 aa) fasta scores: E(): 7.3e-18, 37.22% id in 223 aa, and to Streptomyces coelicolor putative thioredoxin SC8F4.23 TR:Q9L2A3 (EMBL:AL137242) (318 aa) fasta scores: E(): 6.6e-10, 34.06% id in 320 aa, and to Corynebacterium nephridii thioredoxin C-1 SW:THI1_CORNE (P00275) (105 aa) fasta scores: E(): 0.11, 25.96% id in 104 aa. (298 aa)    
Predicted Functional Partners:
trxB
Thioredoxin reductase; Similar to Mycobacterium smegmatis thioredoxin reductase TrxB SW:TRXB_MYCSM (O30973) (311 aa) fasta scores: E(): 3.1e-72, 64.82% id in 307 aa.
  
 
 0.821
nrdE
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.681
DIP1208
Putative secreted protein; No significant database matches.
   
    0.639
DIP0402
Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa.
  
    0.542
groEL1
60 kDa chaperonin 1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.532
groEL2
Chaperonin GroEL2; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.532
DIP1063
Weakly similar to Streptomyces coelicolor putative membrane protein SCL2.30c TR:Q9L269 (EMBL:AL137778) (150 aa) fasta scores: E(): 0.12, 28.3% id in 106 aa.
       0.522
DIP1683
Similar to Streptomyces coelicolor low molecular weight protein-tyrosine-phosphatase PtpA or SCQ11.04c SW:PTPA_STRCO (P53433) (164 aa) fasta scores: E(): 1.3e-21, 47.43% id in 156 aa, and to Bos taurus low molecular weight phosphotyrosine protein phosphatase Acp1 SW:PPAC_BOVIN (P11064) (157 aa) fasta scores: E(): 9.2e-12, 35.55% id in 135 aa.
  
 
 0.522
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
    
 
 0.476
DIP1069
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 39.1 kDa protein Rv3037c or MTV012.52C TR:O53284 (EMBL:AL021287) (358 aa) fasta scores: E(): 3.1e-43, 42.49% id in 353 aa, and to Streptomyces coelicolor Sc6g4.36C protein sc6g4.36C TR:O86799 (EMBL:AL031317) (426 aa) fasta scores: E(): 2.5e-18, 31.36% id in 322 aa.
 
     0.476
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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