Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DIP1069Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 39.1 kDa protein Rv3037c or MTV012.52C TR:O53284 (EMBL:AL021287) (358 aa) fasta scores: E(): 3.1e-43, 42.49% id in 353 aa, and to Streptomyces coelicolor Sc6g4.36C protein sc6g4.36C TR:O86799 (EMBL:AL031317) (426 aa) fasta scores: E(): 2.5e-18, 31.36% id in 322 aa. (394 aa)    
Predicted Functional Partners:
cobIJ
Similar to Mycobacterium tuberculosis cobalamin biosynthesis protein [includes: precorrin-2 C20-methyltransferase; precorrin-3 methylase] CobIJ or Rv2066 or MT2126 or MTCY49.05 SWALL:COBI_MYCTU (SWALL:Q10677) (508 aa) fasta scores: E(): 3.6e-88, 50.7% id in 495 aa, C-terminal region to Rhodobacter capsulatus precorrin-3 methylase SWALL:O68097 (EMBL:AF010496) (245 aa) fasta scores: E(): 1.1e-34, 48.14% id in 243 aa, and N-terminal region to Pseudomonas aeruginosa precorrin-2 methyltransferase CobI or PA2904 SWALL:Q9HZU3 (EMBL:AE004716) (250 aa) fasta scores: E(): 1.4e-33, 43.3% id in 254 aa.
  
  
 0.869
cobM
Similar to Pseudomonas denitrificans precorrin-4 C11-methyltransferase CobM SWALL:COBM_PSEDE (SWALL:P21922) (253 aa) fasta scores: E(): 5.4e-46, 55.37% id in 251 aa, and to Rhodococcus erythropolis precorrin-4 C11-methyltransferase CobM SWALL:COBM_RHOER (SWALL:Q53138) (249 aa) fasta scores: E(): 3.4e-57, 61.04% id in 249 aa.
  
  
 0.742
DIP1068
Putative NUDIX/MutT-family hydrolase; Similar to Mycobacterium tuberculosis hypothetical 31.5 kDa protein Rv3040c or MTV012.55c TR:O53287 (EMBL:AL021287) (288 aa) fasta scores: E(): 4.1e-25, 37.2% id in 258 aa, and to uncultured proteobacterium EBAC31A08 predicted MutT superfamily hydrolase TR:Q9F7R7 (EMBL:AF279106) (264 aa) fasta scores: E(): 8.4e-18, 31.79% id in 239 aa.
       0.738
DIP1784
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv2446c TR:O53173 (EMBL:AL021246) (123 aa) fasta scores: E(): 1.5e-07, 31.35% id in 118 aa, and to Mycobacterium leprae conserved membrane protein ML1470 TR:Q9CBY9 (EMBL:AL583922) (123 aa) fasta scores: E(): 4.9e-07, 30.46% id in 128 aa.
  
     0.683
DIP2067
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 25.3 kDa protein ML0281 or MLCB4.24 SWALL:O69596 (EMBL:AL023514) (229 aa) fasta scores: E(): 6.1e-08, 36.63% id in 202 aa.
  
     0.678
DIP0567
Similar to Mycobacterium leprae hypothetical protein ML0370 TR:Q9CCV6 (EMBL:AL583918) (289 aa) fasta scores: E(): 6.4e-34, 42.46% id in 252 aa.
  
     0.677
DIP0716
Putative secreted protein; Low similarity to Mycobacterium leprae putative membrane protein ML0810 TR:Q9CCH4 (EMBL:AL583919) (407 aa) fasta scores: E(): 1.1e-21, 26.81% id in 414 aa.
  
     0.672
DIP2242
Conserved hypothetical protein; Similar to, but shorter than, Mycobacterium tuberculosis hypothetical 47.0 kDa protein Rv3835 or MTCY01A6.34c TR:P96243 (EMBL:Z83864) (449 aa) fasta scores: E(): 6.4e-31, 34.83% id in 310 aa.
  
     0.670
lpqB
Putative secreted protein; Similar to Mycobacterium tuberculosis hypothetical 61.2 kDa protein LpqB or Rv3244c or MTCY20B11.19c TR:O05889 (EMBL:Z95121) (583 aa) fasta scores: E(): 1.6e-14, 28.76% id in 591 aa.
  
     0.661
DIP0424
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 18.7 kDa protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 1.2e-11, 42.14% id in 121 aa.
  
     0.640
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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