STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1075Similar to Mycobacterium leprae hypothetical protein ML1706 TR:Q9CBR6 (EMBL:AL583923) (337 aa) fasta scores: E(): 4.5e-19, 32.26% id in 313 aa, and to Mycobacterium tuberculosis CDC1551 vitamin-b12 independent methionine synthase family protein MT3095 TR:AAK47424 (EMBL:AE007129) (337 aa) fasta scores: E(): 1.4e-18, 31.94% id in 313 aa, and to Mycobacterium tuberculosis hypothetical 34.2 kDa protein Rv3015c or MTV012.29C TR:O53262 (EMBL:AL021287) (337 aa) fasta scores: E(): 1.4e-18, 31.94% id in 313 aa. (355 aa)    
Predicted Functional Partners:
trmU
Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
     0.812
DIP1611
Similar to Streptomyces lividans 5,10-methylenetetrahydrofolate reductase MetF SW:METF_STRLI (O54235) (307 aa) fasta scores: E(): 4.1e-41, 41.58% id in 303 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF or B3941 SW:METF_ECOLI (P00394) (296 aa) fasta scores: E(): 9.2e-15, 33.65% id in 309 aa.
  
 
 0.760
DIP1686
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 15.2 kDa protein ML1649 or MLCB1243.26 TR:O69479 (EMBL:AL023635) (140 aa) fasta scores: E(): 4.1e-24, 56.55% id in 122 aa.
  
     0.748
DIP0679
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 23.7 kDa protein Rv3268 or MTCY71.08 TR:P96873 (EMBL:Z92771) (229 aa) fasta scores: E(): 7.6e-11, 31.48% id in 235 aa.
  
    0.735
priA
Putative primosomal protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
  
     0.718
DIP1073
Putative transferase; Similar to Streptomyces coelicolor hypothetical 30.6 kDa protein 2scc13.11C TR:Q9F3H8 (EMBL:AL442165) (289 aa) fasta scores: E(): 5.6e-28, 36.2% id in 279 aa, and to Neisseria meningitidis (serogroup A), and putative transferase nma1087 or nmb0869 TR:Q9JQL8 (EMBL:AL162755) (263 aa) fasta scores: E(): 1.6e-09, 26.42% id in 246 aa, and to Escherichia coli spermidine synthase spee or B0121 SW:SPEE_ECOLI (P09158) (287 aa) fasta scores: E(): 0.0013, 28.28% id in 152 aa.
 
   
 0.704
DIP1243
Conserved hypothetical protein; Similar to Rhodococcus erythropolis ORF11 SWALL:P72265 (EMBL:Z82004) (326 aa) fasta scores: E(): 1.3e-24, 31.42% id in 315 aa, and to Mycobacterium tuberculosis hypothetical 33.8 kDa protein Rv2095c precursor or MT2156 or MTCY49.35c SWALL:YK95_MYCTU (SWALL:Q10704) (316 aa) fasta scores: E(): 3.4e-24, 31.57% id in 304 aa.
  
     0.683
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.664
DIP1815
Putative lipoprotein; Similar to Mycobacterium tuberculosis hypothetical protein Rv2518c TR:O53223 (EMBL:AL021185) (408 aa) fasta scores: E(): 6.9e-67, 53.02% id in 347 aa, and to Mycobacterium leprae putative secreted protein ML0426 TR:Q9CCU5 (EMBL:AL583918) (404 aa) fasta scores: E(): 5.2e-63, 49.28% id in 349 aa.
  
     0.651
DIP2293
Similar to Streptomyces coelicolor putative transmembrane protein SCH24.24 SWALL:Q9X8T8 (EMBL:AL049826) (502 aa) fasta scores: E(): 7.8e-37, 36.2% id in 453 aa.
  
     0.648
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.