STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1076Putative DNA polymerase; Similar to Streptomyces coelicolor putative DNA polymerase SCBAC1A6.08 TR:Q9ADH9 (EMBL:AL589708) (244 aa) fasta scores: E(): 2.6e-12, 42.06% id in 233 aa, and to Rhodobacter capsulatus DNA polymerase III epsilon chain-like protein DnaQ SW:DP3E_RHOCA (O68045) (704 aa) fasta scores: E(): 0.0033, 31.7% id in 164 aa. (234 aa)    
Predicted Functional Partners:
dnaX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 
 0.945
dnaE
Similar to Streptomyces coelicolor DNA polymerase III alpha subunit DnaE or SC4G6.33c SW:DP3A_STRCO (Q9Z618) (1179 aa) fasta scores: E(): 0, 53.84% id in 1185 aa, and to Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or B0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 6.2e-94, 35.39% id in 1198 aa.
  
 
 0.941
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
   
 0.939
DIP1769
Similar to Mycobacterium tuberculosis hypothetical protein Rv2413c TR:AAK46782 (EMBL:Z81368) (322 aa) fasta scores: E(): 1.9e-40, 42.63% id in 319 aa, and to Streptomyces coelicolor putative DNA-binding protein SCC123.02c TR:Q9RDM2 (EMBL:AL136518) (336 aa) fasta scores: E(): 6.3e-33, 37.69% id in 321 aa.
  
 
 0.934
DIP0333
Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, delta' subunit MT3747 TR:AAK48107 (EMBL:AE007173) (404 aa) fasta scores: E(): 1.4e-57, 46.59% id in 397 aa, and to Escherichia coli DNA polymerase III, delta' subunit HolB or B1099 SW:HOLB_ECOLI (P28631) (334 aa) fasta scores: E(): 6.9e-11, 28.61% id in 304 aa.
    
  0.921
DIP1573
Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit CAC0738 TR:AAK78714 (EMBL:AE007589) (306 aa) fasta scores: E(): 1.4e-14, 28.9% id in 339 aa, and to the exonuclease domain of Bacillus halodurans DNA polymerase III PolC-type PolC or BH2418 SW:DPO3_BACHD (Q9KA72) (1433 aa) fasta scores: E(): 2.7e-08, 28.62% id in 248 aa.
 
  
  0.915
DIP0264
Putative helicase; Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, epsilon subunit MT3814 TR:AAK48182 (EMBL:AE007178) (329 aa) fasta scores: E(): 1.3e-07, 25.37% id in 335 aa, and to Bacillus subtilis probable ATP-dependent helicase DinG homolog SW:DING_BACSU (P54394) (931 aa) fasta scores: E(): 0.48, 24.07% id in 108 aa.
  
  
  0.913
recN
DNA repair protein; May be involved in recombinational repair of damaged DNA.
  
  
 0.699
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
       0.683
DIP2281
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 44.0 kDa protein SC4G6.31c SWALL:Q9S2S7 (EMBL:AL096884) (403 aa) fasta scores: E(): 4.6e-09, 25.49% id in 459 aa.
 
     0.507
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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