STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1090Putative aldo/keto-reductase family protein; Similar to Escherichia coli ORF_O346 B3001 TR:Q46851 (EMBL:U28377) (346 aa) fasta scores: E(): 2.5e-73, 56.21% id in 354 aa, to Streptomyces coelicolor putative oxidoreductase SC7H9.06 TR:Q9EWJ0 (EMBL:AL450223) (348 aa) fasta scores: E(): 1.6e-65, 58.48% id in 342 aa, and to Homo sapiens voltage-gated potassium channel beta-2 subunit KcnAB2 or KcnA2B or KcnK2 TR:Q13303 (EMBL:U33429) (367 aa) fasta scores: E(): 9.5e-27, 34.74% id in 331 aa. (365 aa)    
Predicted Functional Partners:
glpF
Similar to Bacillus subtilis glycerol uptake facilitator protein GlpF SW:GLPF_BACSU (P18156) (274 aa) fasta scores: E(): 2.1e-23, 45.83% id in 240 aa; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
 
 0.699
gatB
glutamyl-tRNA(Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.
  
    0.684
DIP0057
Similar to Mycobacterium leprae probable phosphoprotein phosphatase Ppp TR:Q50188 (EMBL:Z70722) (509 aa) fasta scores: E(): 5.8e-46, 43.64% id in 488 aa.
    
   0.544
DIP0788
Similar to Streptomyces coelicolor putative oxidoreductase SC4B5.01c TR:Q9ZBW7 (EMBL:AL034443) (277 aa) fasta scores: E(): 1.3e-48, 48% id in 275 aa, and to Corynebacterium sp 2,5-diketo-D-gluconic acid reductase SW:2DKG_CORSP (P15339) (277 aa) fasta scores: E(): 1.1e-39, 44.52% id in 274 aa.
 
 
0.543
ppiA
Probable peptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
    
   0.487
DIP1363
Putative isomerase; Similar to Mycobacterium tuberculosis probable peptidyl-prolyl cis-trans isomerase B PpiB or Ppi or Rv2582 or MT2659 or MTCY227.19c SWALL:PPIB_MYCTU (SWALL:Q50639) (308 aa) fasta scores: E(): 5.5e-37, 46.23% id in 292 aa, and to Streptomyces coelicolor putative peptidyl-prolyl cis-trans isomerase SC9C5.34 SWALL:Q9KXP0 (EMBL:AL357523) (277 aa) fasta scores: E(): 3.5e-26, 37.5% id in 288 aa.
    
   0.487
dnaJ2
Chaperone protein 2; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
    
   0.448
dnaJ1
Chaperone protein cofactor 1; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between D [...]
    
   0.448
ndk
Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
   0.439
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
  
 
 0.409
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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