Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lysGSimilar to Corynebacterium glutamicum lysine export transcriptional regulatory protein LysG SW:LYSG_CORGL (P94632) (290 aa) fasta scores: E(): 3.2e-70, 62.54% id in 291 aa, and to Streptomyces coelicolor putative LysR-family transcriptional regulator SC5F8.17c TR:Q9K4K7 (EMBL:AL357613) (300 aa) fasta scores: E(): 3.8e-43, 46.8% id in 297 aa, and to Rhodococcus fascians AttR protein TR:CAC43333 (EMBL:AJ311775) (320 aa) fasta scores: E(): 2.2e-37, 43.43% id in 297 aa. (293 aa)    
Predicted Functional Partners:
lysE
Lysine exporter protein; Catalyzes the efflux of L-lysine. Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
 
   
 0.990
DIP2250
Putative membrane protein; Region similar to many eg. Streptomyces coelicolor putative membrane protein SCBAC19G2.03c TR:CAC44513 (EMBL:AL596138) (397 aa) fasta scores: E(): 4.6e-19, 36.91% id in 409 aa, and to Staphylococcus aureus (strain N315), and SA2103 protein or SAV2310 TR:BAB58472 (EMBL:AP003136) (315 aa) fasta scores: E(): 4.5e-13, 31.07% id in 280 aa.
   
    0.745
DIP1296
Putative DNA-binding protein; Similar to Mycobacterium tuberculosis hypothetical 29.2 kDa protein Rv1460 or MTV007.07 SWALL:O53151 (EMBL:AL021184) (278 aa) fasta scores: E(): 3.4e-38, 46.25% id in 240 aa, and to Streptomyces coelicolor putative DNA-binding protein scc22.08C SWALL:Q9XAD0 (EMBL:AL096839) (252 aa) fasta scores: E(): 9e-27, 42.35% id in 229 aa.
   
    0.744
DIP2129
Putative binding-protein-dependent integral membrane transport protein; Similar to Mycobacterium tuberculosis putative phosphate permease Rv2281 or MT2339 or MTCY339.29C SW:YM81_MYCTU (Q50684) (552 aa) fasta scores: E(): 1.2e-121, 61% id in 518 aa.
      
 0.671
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.613
DIP0303
Putative transcription regulator; Similar to Corynebacterium glutamicum probable transcription regulator TR:AAK58838 (EMBL:AF293334) (227 aa) fasta scores: E(): 8e-79, 91.18% id in 227 aa, and to Escherichia coli catabolite gene activator Crp or Cap or Csm or B3357 or Z4718 or ECS4208 SW:CRP_ECOLI (P03020) (210 aa) fasta scores: E(): 4.6e-15, 33.68% id in 190 aa.
   
 
 0.582
DIP0619
Putative diphtheria toxin repressor 2; Similar to Mycobacterium tuberculosis iron-dependent repressor IdeR or DtxR or Rv2711 or MT2784 or MTCY05A6.32 SW:IDER_MYCTU (Q50495) (230 aa) fasta scores: E(): 1.1e-10, 31.84% id in 201 aa and low similarity to Corynebacterium diphtheriae diphtheria toxin repressor DtxR SW:DTXR_CORDI (P33120) (226 aa) fasta scores: E(): 7.7e-08, 35.08% identity in 114 aa overlap.
   
 
 0.544
DIP1615
Similar to Streptomyces coelicolor eukaryotic-type protein kinase PkaF TR:Q9ZNB3 (EMBL:AB019394) (629 aa) fasta scores: E(): 8.2e-37, 36.22% id in 646 aa.
      
 0.498
pknA
Similar to Mycobacterium leprae probable serine/threonine-protein kinase PnkA or ML0017 SW:PKNA_MYCLE (P54743) (437 aa) fasta scores: E(): 4e-37, 41.99% id in 431 aa.
      
 0.497
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.483
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.