STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1101Cation-efflux system integral membrane protein; Similar to Staphylococcus aureus (strain N315) CzrB protein or SA1948 or SAV2146 TR:BAB58308 (EMBL:AP003136) (325 aa) fasta scores: E(): 4e-37, 37.74% id in 302 aa, and to Alcaligenes eutrophus cobalt-zinc-cadmium resistance protein CzcD SW:CZCD_ALCEU (P13512) (316 aa) fasta scores: E(): 9.2e-36, 40.84% id in 284 aa. (307 aa)    
Predicted Functional Partners:
DIP1103
Hypothetical protein; No significant database matches.
       0.656
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
       0.653
DIP1102
Conserved hypothetical protein; Similar to Anabaena sp All3615 protein TR:BAB75314 (EMBL:AP003593) (621 aa) fasta scores: E(): 1.8e-37, 29.29% id in 594 aa, and to Streptomyces coelicolor hypothetical 67.8 kDa protein SC4G2.12c TR:O86684 (EMBL:AL031371) (605 aa) fasta scores: E(): 9.5e-29, 34.55% id in 602 aa.
       0.634
ilvH
Similar to Mycobacterium tuberculosis acetolactate synthase small subunit IlvH or IlvN or Rv3002c or MT3082 or MTV012.16c SW:ILVH_MYCTU (O53249) (168 aa) fasta scores: E(): 1.3e-28, 54.77% id in 157 aa, and to Corynebacterium glutamicum (Brevibacterium flavum) acetohydroxy acid synthase, small subunit IlvN or LivS TR:Q57091 (EMBL:L09232) (172 aa) fasta scores: E(): 5.4e-47, 81.06% id in 169 aa.
  
    0.562
ilvB
Similar to Corynebacterium glutamicum acetolactate synthase large subunit IlvB SW:ILVB_CORGL (P42463) (626 aa) fasta scores: E(): 4.3e-181, 75.32% id in 620 aa, and to Mycobacterium tuberculosis acetolactate synthase IlvB or Rv3003c or MT3083 or MTV012.17c SW:ILVB_MYCTU (O53250) (618 aa) fasta scores: E(): 1.6e-152, 64.94% id in 599 aa.
  
    0.551
serA
Similar to Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase SerA or Rv2996c or MT3074 or MTV012.10 SW:SERA_MYCTU (O53243) (528 aa) fasta scores: E(): 3.6e-129, 67.56% id in 521 aa, and to Homo sapiens D-3-phosphoglycerate dehydrogenase PhgDH SW:SERA_HUMAN (O43175) (533 aa) fasta scores: E(): 1.4e-43, 34.47% id in 438 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
       0.546
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
   
   0.523
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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