STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serASimilar to Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase SerA or Rv2996c or MT3074 or MTV012.10 SW:SERA_MYCTU (O53243) (528 aa) fasta scores: E(): 3.6e-129, 67.56% id in 521 aa, and to Homo sapiens D-3-phosphoglycerate dehydrogenase PhgDH SW:SERA_HUMAN (O43175) (533 aa) fasta scores: E(): 1.4e-43, 34.47% id in 438 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)    
Predicted Functional Partners:
DIP0784
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
 
 0.987
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
  
  
 0.910
gpmA
Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
 
   
  0.900
cysE
Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 9.3e-33, 55.68% id in 167 aa, and to Azotobacter vinelandii O-acetylserine synthase CysE2 TR:O69218 (EMBL:AF010139) (251 aa) fasta scores: E(): 6.1e-38, 58.85% id in 175 aa.
      
 0.713
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
  
 0.635
DIP1103
Hypothetical protein; No significant database matches.
       0.629
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.606
thrA
Similar to Corynebacterium glutamicum homoserine dehydrogenase Hom or ThrA SW:DHOM_CORGL (P08499) (445 aa) fasta scores: E(): 4.2e-117, 75.28% id in 437 aa, and to Bacillus subtilis homoserine dehydrogenase Hom or Tdm SW:DHOM_BACSU (P19582) (433 aa) fasta scores: E(): 4.2e-54, 40.18% id in 433 aa.
  
 
 0.569
ilvH
Similar to Mycobacterium tuberculosis acetolactate synthase small subunit IlvH or IlvN or Rv3002c or MT3082 or MTV012.16c SW:ILVH_MYCTU (O53249) (168 aa) fasta scores: E(): 1.3e-28, 54.77% id in 157 aa, and to Corynebacterium glutamicum (Brevibacterium flavum) acetohydroxy acid synthase, small subunit IlvN or LivS TR:Q57091 (EMBL:L09232) (172 aa) fasta scores: E(): 5.4e-47, 81.06% id in 169 aa.
  
  
 0.553
pyk
Pyruvate kinase; Similar to Corynebacterium glutamicum pyruvate kinase Pyk SW:KPYK_CORGL (Q46078) (475 aa) fasta scores: E(): 1.3e-146, 83.36% id in 469 aa, and to Bacillus psychrophilus pyruvate kinase Pyk SW:KPYK_BACPY (P51182) (586 aa) fasta scores: E(): 6.9e-64, 41.45% id in 480 aa.
    
 0.551
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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