STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1114Similar to Bacillus subtilis isochorismate synthase DhbC SW:DHBC_BACSU (P45744) (398 aa) fasta scores: E(): 1.9e-43, 41.01% id in 356 aa, and to Stigmatella aurantiaca MxcD TR:Q9F639 (EMBL:AF299336) (408 aa) fasta scores: E(): 7e-40, 36.91% id in 382 aa, and to Vibrio cholerae vibriobactin-specific isochorismate synthase VibC or VC0773 SW:VIBC_VIBCH (O07898) (395 aa) fasta scores: E(): 2.8e-31, 35.45% id in 330 aa. (377 aa)    
Predicted Functional Partners:
menD
Putative menaquinone biosynthesis protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
 0.983
DIP2189
Putative polyketide synthase; Similar to Mycobacterium tuberculosis polyketide synthase PKS13 or Rv3800c or MTV026.05c TR:O53579 (EMBL:AL022076) (1733 aa) fasta scores: E(): 5.4e-109, 44.5% id in 1719 aa, and to Polyangium cellulosum soraphen polyketide synthase A SorA TR:Q9ADL6 (EMBL:U24241) (6315 aa) fasta scores: E(): 6.2e-101, 35.96% id in 1090 aa.
 
  
 0.943
trpG
Similar to Corynebacterium glutamicum anthranilate synthase component II TrpG SW:TRPG_CORGL (P06558) (208 aa) fasta scores: E(): 5.8e-52, 65.23% id in 210 aa.
  
  
 0.941
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.895
DIP0834
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 11.8 kDa protein Rv0948c or MT0975 or MTCY10D7.26 SW:Y948_MYCTU (P71562) (105 aa) fasta scores: E(): 1.6e-14, 62.35% id in 85 aa.
  
 
 0.885
trpE
Similar to Corynebacterium glutamicum anthranilate synthase component I TrpE SW:TRPE_CORGL (P06557) (518 aa) fasta scores: E(): 5.7e-128, 65.44% id in 518 aa, and to Escherichia coli anthranilate synthase component I trpE or b1264 SW:TRPE_ECOLI (P00895) (520 aa) fasta scores: E(): 6.3e-66, 47.44% id in 508 aa.
  
  
0.861
DIP1006
Similar to Deinococcus radiodurans shikimate 5-dehydrogenase, putative DR0077 TR:Q9RY73 (EMBL:AE001871) (273 aa) fasta scores: E(): 1.2e-48, 54.3% id in 267 aa, and to Haemophilus influenzae hypothetical shikimate 5-dehydrogenase-like protein Hi0607 hi0607 SW:YDIB_HAEIN (P44774) (271 aa) fasta scores: E(): 1.4e-45, 49.25% id in 268 aa, and to Escherichia coli hypothetical shikimate 5-dehydrogenase-like protein ydib ydib or B1692 SW:YDIB_ECOLI (P28244) (288 aa) fasta scores: E(): 1.9e-09, 30.03% id in 263 aa.
  
  
 0.846
menB
Putative naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
   
 0.820
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
     
 0.807
pat
Putative aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
     
  0.800
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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