STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1135Putative kinase; Similar to Mycobacterium tuberculosis hypothetical 46.7 kDa protein Rv2974c or MTCY349.13 TR:P95121 (EMBL:Z83018) (470 aa) fasta scores: E(): 4e-28, 33.402% id in 485 aa, and to Clostridium acetobutylicum predicted kinase related to hydroxyacetone kinase YloV ortholog CAC1735 TR:AAK79701 (EMBL:AE007682) (547 aa) fasta scores: E(): 3.8e-21, 25.690% id in 471 aa. (501 aa)    
Predicted Functional Partners:
DIP1772
Similar to Mycobacterium tuberculosis hypothetical protein Rv2417c TR:P71726 (EMBL:Z81368) (280 aa) fasta scores: E(): 1e-21, 34.92% id in 272 aa, and to Streptomyces coelicolor hypothetical protein SCC123.07c TR:Q9RDL7 (EMBL:AL136518) (281 aa) fasta scores: E(): 6e-21, 36.13% id in 274 aa.
 
   0.930
recG
Similar to Bacillus subtilis ATP-dependent DNA helicase RecG SW:RECG_BACSU (O34942) (682 aa) fasta scores: E(): 3.3e-69, 33.862% id in 694 aa, and to Escherichia coli ATP-dependent DNA helicase RecG or B3652 SW:RECG_ECOLI (P24230) (693 aa) fasta scores: E(): 8.9e-63, 34.765% id in 722 aa.
  
    0.915
DIP1693
Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily.
      
 0.853
DIP1138
Putative DNA methylase; Similar to Mycobacterium tuberculosis hypothetical 19.8 kDa protein Rv2966c or MTCY349.21 TR:P95128 (EMBL:Z83018) (188 aa) fasta scores: E(): 2.6e-22, 42.703% id in 185 aa, and to Streptomyces coelicolor putative methylase SC7A1.11 TR:Q9ZBR2 (EMBL:AL034447) (195 aa) fasta scores: E(): 1.2e-21, 44.505% id in 182 aa.
 
     0.826
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
     0.820
DIP1137
Putative biotin carboxyl carrier protein; Similar to C-terminus of Mycobacterium smegmatis pyruvate carboxylase Pyc TR:Q9F843 (EMBL:AF262949) (1127 aa) fasta scores: E(): 1.9e-05, 47.761% id in 67 aa, to Bacillus subtilis YngXX TR:Q9R9I3 (EMBL:AF184956) (73 aa) fasta scores: E(): 0.0043, 36.765% id in 68 aa, and to Propionibacterium freudenreichii shermanii biotin carboxyl carrier protein of methylmalonyl-CoA carboxyl- transferase SW:BCCP_PROFR (P02904) (123 aa) fasta scores: E(): 0.0079, 38.806% id in 67 aa.
       0.784
DIP1140
Putative membrane protein; No significant database matches.
       0.659
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
       0.646
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
       0.646
DIP1132
Putative exported protein; Similar to Mycobacterium leprae possible secreted protein ML1677 TR:Q9CBS1 (EMBL:AL583923) (191 aa) fasta scores: E(): 8.9e-13, 32.447% id in 188 aa, and to Mycobacterium tuberculosis hypothetical 18.8 kDa protein Rv2980 or MTCY349.07c TR:P95115 (EMBL:Z83018) (181 aa) fasta scores: E(): 1.5e-09, 31.098% id in 164 aa.
       0.569
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.