STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (899 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
 
 0.999
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
  
 0.999
DIP1025
Putative exonuclease, SbcD-family; Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa.
   
 0.993
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.988
DIP0333
Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, delta' subunit MT3747 TR:AAK48107 (EMBL:AE007173) (404 aa) fasta scores: E(): 1.4e-57, 46.59% id in 397 aa, and to Escherichia coli DNA polymerase III, delta' subunit HolB or B1099 SW:HOLB_ECOLI (P28631) (334 aa) fasta scores: E(): 6.9e-11, 28.61% id in 304 aa.
   
 0.971
DIP1026
Similar to Mycobacterium leprae hypothetical protein ML1120 TR:Q9CC83 (EMBL:AL583920) (873 aa) fasta scores: E(): 1.9e-14, 28.49% id in 888 aa, and to Mycobacterium tuberculosis hypothetical 93.4 kDa protein Rv1278 or MT1315 or MTCY50.04c SW:YC78_MYCTU (Q11042) (875 aa) fasta scores: E(): 3.3e-13, 29% id in 893 aa. Contains coiled-coil domains, and thus some probably non-specific similarity to e.g. Drosophila melanogaster myosin heavy chain, non-muscle zip SW:MYSN_DROME (Q99323) (2017 aa) fasta scores: E(): 5.7e-07, 23.06% id in 568 aa.
  
 0.971
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 0.951
pheT
Similar to Mycobacterium tuberculosis phenylalanyl-tRNA synthetase beta chain PheT or Rv1650 or MT1688 or MTCY06H11.15 SWALL:SYFB_MYCTU (SWALL:P94985) (831 aa) fasta scores: E(): 4.2e-156, 49.64% id in 844 aa, and to Bacillus subtilis phenylalanyl-tRNA synthetase beta chain PheT SWALL:SYFB_BACSU (SWALL:P17922) (804 aa) fasta scores: E(): 1.8e-53, 30.69% id in 847 aa.
 
  
 0.933
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
  
 0.929
DIP1859
DeaD/DeaH family helicase; Similar to Escherichia coli probable ATP-dependent helicase DinG SW:DING_ECOLI (P27296) (716 aa) fasta scores: E(): 5.6e-15, 27.57% id in 689 aa, and to Mycobacterium tuberculosis probable ATP-dependent helicase DinG homologue Rv1329c SW:DING_MYCTU (Q10640) (664 aa) fasta scores: E(): 2.2e-131, 55.84% id in 659 aa.
   
 0.920
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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