Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
ptsGSimilar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa. (676 aa)    
Predicted Functional Partners:
ptsI
Phosphoenolpyruvate:sugar phosphotransferase system enzyme I (PTS system); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 0.997
DIP1435
Putative fructose-specific IIBC (PTS system) (pseudogene); HMMPfam hit to PF02378, Phosphotransferase system, EIIC.
 
 0.993
DIP1150
Similar to Bacillus subtilis transcription antiterminator LicT or N15A SWALL:LICT_BACSU (SWALL:P39805) (277 aa) fasta scores: E(): 2.6e-20, 28.72% id in 275 aa, and to Escherichia coli cryptic beta-glucoside Bgl operon antiterminator BglG or BglC or B3723 SWALL:BGLG_ECOLI (SWALL:P11989) (278 aa) fasta scores: E(): 1.4e-18, 27.33% id in 278 aa.
 
 0.991
ppgK
Polyphosphate glucokinase; Similar to Mycobacterium tuberculosis polyphosphate glucokinase PpgK or Rv2702 or MT2776 or MTCY05A6.23 SW:PPGK_MYCTU (Q59568) (265 aa) fasta scores: E(): 1.5e-50, 57.91% id in 240 aa, and to Corynebacterium ammoniagenes polyphosphate glucokinase PpgK TR:Q9AGV8 (EMBL:AF326348) (277 aa) fasta scores: E(): 3.2e-59, 63.85% id in 249 aa.
  
 
 0.981
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
  
 
 0.965
DIP0989
Putative hydrolase; Similar to the N-terminal region of Pichia jadinii beta-D-fructofuranoside fructohydrolase Inv1 TR:O94224 (EMBL:Y12659) (533 aa) fasta scores: E(): 1.5e-09, 26.33% id in 300 aa, and to the C-terminal region of Pseudomonas mucidolens endo-inulinase TR:Q9RGC0 (EMBL:AF141320) (776 aa) fasta scores: E(): 3.6e-07, 21.77% id in 473 aa.
 
  
 0.961
DIP0123
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 46.1 kDa protein Rv0485 or MT0503 or MTCY20G9.11 SW:Y485_MYCTU (Q11151) (438 aa) fasta scores: E(): 1.4e-12, 32.14% id in 224 aa.
  
 
 0.960
DIP0518
Putative regulatory protein sugar kinase; Similar to Streptomyces coelicolor glucokinase Glk or SC6E10.20c SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 8e-13, 30.91% id in 317 aa.
  
 
 0.960
glk
Glucose kinase; Similar to Corynebacterium glutamicum glucose kinase Glk TR:Q9KKE7 (EMBL:AF096280) (323 aa) fasta scores: E(): 2.5e-79, 62.38% id in 319 aa, and to Streptomyces coelicolor glucokinase Glk or SC6E10.20c SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 5.7e-45, 40% id in 310 aa.
  
 
 0.960
DIP2336
Similar to but longer than a family of hypothetical proteins eg. Deinococcus radiodurans conserved hypothetical protein DRB0052 SWALL:Q9RZR3 (EMBL:AE001826) (133 aa) fasta scores: E(): 8.8e-10, 43.75% id in 128 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0607 or SAV0652 SWALL:Q99VW9 (EMBL:AP003131) (120 aa) fasta scores: E(): 1.3e-09, 42.73% id in 117 aa.
 
 
 0.920
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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