STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1153Similar to Archaeoglobus fulgidus coenzyme PQQ synthesis protein AF2413 SWALL:O30258 (EMBL:AE001109) (375 aa) fasta scores: E(): 1.1e-54, 40.79% id in 375 aa, and to Methylobacterium extorquens coenzyme PQQ synthesis protein E PqqE SWALL:PQQE_METEX (SWALL:P71517) (384 aa) fasta scores: E(): 1e-05, 24.67% id in 381 aa. (399 aa)    
Predicted Functional Partners:
hemH
Putative ferrochelatase (protoheme biosynthesis); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
 
 0.913
ctaB
Putative farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
  0.900
hmuO
Heme oxygenase; Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.
     
  0.900
DIP0402
Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa.
 
  
 0.587
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
       0.545
DIP2170
Conserved hypothetical integral membrane protein; Similar to Bacillus subtilis hypothetical 27.6 kDa protein in fnr-narG intergenic region YwiC SW:YWIC_BACSU (P46909) (239 aa) fasta scores: E(): 5e-08, 28.571% id in 259 aa, and to Haemophilus influenzae hypothetical protein HI1626 SW:YG26_HAEIN (P44278) (238 aa) fasta scores: E(): 3.6e-06, 25.758% id in 264 aa.
 
     0.472
DIP1876
Putative multicopper oxidase; C-terminus is similar to an internal regions of Neisseria gonorrhoeae major anaerobically induced outer membrane protein Pan 1 AniA SW:ANIA_NEIGO (Q02219) (392 aa) fasta scores: E(): 3.5e-18, 30.1% id in 299 aa, and Neisseria meningitidis nitrite reductase, major outer membrane copper-containing protein NMA1887 TR:Q9JTB8 (EMBL:AL162757) (386 aa) fasta scores: E(): 3e-18, 30.43% id in 299 aa.
 
  
 0.455
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
       0.440
DIP1877
Putative membrane protein; No significant database matches to the full length CDS. C-terminus is similar to the N-terminal regions of Rhizobium meliloti hypothetical protein SMA0447 TR:AAK64892 (EMBL:AE007216) (373 aa) fasta scores: E(): 0.48, 22.94% id in 353 aa.
 
  
 0.438
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.