STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1158Putative hydrolase; Similar to Mycobacterium tuberculosis CDC1551 metallo-beta-lactamase superfamily protein MT1673 SWALL:AAK45943 (EMBL:AE007031) (264 aa) fasta scores: E(): 5e-29, 45.58% id in 204 aa, and to Streptomyces coelicolor putative hydrolase SCC54.20 SWALL:Q9Z505 (EMBL:AL035591) (218 aa) fasta scores: E(): 7.2e-26, 40.55% id in 217 aa. (215 aa)    
Predicted Functional Partners:
DIP1157
Conserved hypothetical protein; N-terminal region similar to Streptomyces coelicolor hypothetical 18.8 kDa protein SC9H11.26c SWALL:Q9KYL5 (EMBL:AL356592) (177 aa) fasta scores: E(): 9.8e-11, 35.13% id in 148 aa. Note: Possible colied-coil region at C-terminal domain from residue 242 till the end.
 
     0.693
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
       0.683
DIP1748
Putative oxidase; Similar to Lactococcus lactis NADH oxidase NoxC TR:Q9CHE6 (EMBL:AE006312) (547 aa) fasta scores: E(): 5.8e-81, 44.95% id in 545 aa, and to Enterococcus faecalis NADH oxidase Nox SW:NAOX_ENTFA (P37061) (446 aa) fasta scores: E(): 3.8e-30, 27.46% id in 437 aa.
  
 0.657
DIP1156
Putative helicase; Similar to Streptomyces coelicolor putative helicase protein SCE59.11c SWALL:Q9L1U3 (EMBL:AL138851) (744 aa) fasta scores: E(): 5.4e-32, 34.77% id in 788 aa, and to Clostridium acetobutylicum superfamily I DNA helicase CAC1026 SWALL:AAK79002 (EMBL:AE007618) (763 aa) fasta scores: E(): 2e-15, 23.98% id in 788 aa.
       0.548
infC
Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
       0.538
rpmI
Similar to Streptomyces coelicolor 50S ribosomal protein L35 RpmI or SCI35.21c SWALL:RL35_STRCO (SWALL:O88059) (64 aa) fasta scores: E(): 1.1e-10, 58.06% id in 62 aa, and to Bacillus subtilis 50S ribosomal protein L35 RpmI SWALL:RL35_BACSU (SWALL:P55874) (65 aa) fasta scores: E(): 1.5e-07, 50% id in 60 aa; Belongs to the bacterial ribosomal protein bL35 family.
       0.515
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
   
 
 0.510
DIP2189
Putative polyketide synthase; Similar to Mycobacterium tuberculosis polyketide synthase PKS13 or Rv3800c or MTV026.05c TR:O53579 (EMBL:AL022076) (1733 aa) fasta scores: E(): 5.4e-109, 44.5% id in 1719 aa, and to Polyangium cellulosum soraphen polyketide synthase A SorA TR:Q9ADL6 (EMBL:U24241) (6315 aa) fasta scores: E(): 6.2e-101, 35.96% id in 1090 aa.
    
 
 0.452
DIP0653
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 14.5 kDa protein ML0284 or MLCB4.27c TR:O69598 (EMBL:AL023514) (137 aa) fasta scores: E(): 3.5e-22, 50% id in 140 aa.
  
     0.429
DIP1462
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 23.6 kDa protein SC4G6.14 TR:Q9S2U0 (EMBL:AL096884) (211 aa) fasta scores: E(): 1.4e-09, 31.86% id in 204 aa, and to Mycobacterium tuberculosis hypothetical 24.0 kDa protein Rv1929c or MTCY09F9.35 TR:P95285 (EMBL:Z84498) (214 aa) fasta scores: E(): 4.3e-07, 32.71% id in 217 aa.
  
     0.428
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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