STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (953 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 0.998
uvrC
Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 0.912
uvrA2
Similar to Pseudomonas lemoignei putative excinuclease ABC subunit A UvrA SWALL:UVRA_PSELE (SWALL:P52087) (689 aa) fasta scores: E(): 1.1e-73, 60.02% id in 703 aa, and to Micrococcus luteus excinuclease ABC subunit A UvrA SWALL:UVRA_MICLU (SWALL:P13567) (992 aa) fasta scores: E(): 8.7e-50, 38.63% id in 1012 aa, and to Streptomyces coelicolor excinuclease ABC subunit A Uvra or SCC54.18c SWALL:UVRA_STRCO (SWALL:Q9Z507) (1014 aa) fasta scores: E(): 2.8e-49, 39.67% id in 993 aa.
  
  
 
0.910
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
   
 
 0.789
infC
Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
     
 0.779
rpmI
Similar to Streptomyces coelicolor 50S ribosomal protein L35 RpmI or SCI35.21c SWALL:RL35_STRCO (SWALL:O88059) (64 aa) fasta scores: E(): 1.1e-10, 58.06% id in 62 aa, and to Bacillus subtilis 50S ribosomal protein L35 RpmI SWALL:RL35_BACSU (SWALL:P55874) (65 aa) fasta scores: E(): 1.5e-07, 50% id in 60 aa; Belongs to the bacterial ribosomal protein bL35 family.
     
 0.746
rplT
50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
     
 0.717
DIP1158
Putative hydrolase; Similar to Mycobacterium tuberculosis CDC1551 metallo-beta-lactamase superfamily protein MT1673 SWALL:AAK45943 (EMBL:AE007031) (264 aa) fasta scores: E(): 5e-29, 45.58% id in 204 aa, and to Streptomyces coelicolor putative hydrolase SCC54.20 SWALL:Q9Z505 (EMBL:AL035591) (218 aa) fasta scores: E(): 7.2e-26, 40.55% id in 217 aa.
       0.683
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.643
pcrA
Similar to Mycobacterium leprae ATP-dependent DNA helicase PcrA or UvrD or ML0153 SW:PCRA_MYCLE (Q9CD72) (778 aa) fasta scores: E(): 5.7e-165, 59.08% id in 804 aa, and to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 4.1e-80, 42.76% id in 802 aa.
 
 
 0.612
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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