STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tsnRPutative rRNA methyltransferase; Similar to Mycobacterium tuberculosis TsnR or Rv1644 or MT1682 or MTCY06H11.08 SWALL:AAK45951 (EMBL:Z85982) (260 aa) fasta scores: E(): 2.4e-45, 52.85% id in 263 aa, and to Mycobacterium leprae putative rRNA methyltransferase TsnR or ML1397 SWALL:Q9CC19 (EMBL:AL583921) (259 aa) fasta scores: E(): 6.7e-45, 52.89% id in 259 aa, and to Bacillus halodurans rRNA methylase BH3112 SWALL:Q9K894 (EMBL:AP001517) (251 aa) fasta scores: E(): 3.2e-17, 35.24% id in 244 aa; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase T [...] (272 aa)    
Predicted Functional Partners:
pheT
Similar to Mycobacterium tuberculosis phenylalanyl-tRNA synthetase beta chain PheT or Rv1650 or MT1688 or MTCY06H11.15 SWALL:SYFB_MYCTU (SWALL:P94985) (831 aa) fasta scores: E(): 4.2e-156, 49.64% id in 844 aa, and to Bacillus subtilis phenylalanyl-tRNA synthetase beta chain PheT SWALL:SYFB_BACSU (SWALL:P17922) (804 aa) fasta scores: E(): 1.8e-53, 30.69% id in 847 aa.
 
  
 0.734
pheS
Similar to Mycobacterium tuberculosis phenylalanyl-tRNA synthetase alpha chain PheS or Rv1649 or MT1687 or MTCY06H11.14 SWALL:SYFA_MYCTU (SWALL:P94984) (341 aa) fasta scores: E(): 6.6e-87, 62.35% id in 340 aa, and to Bacillus subtilis phenylalanyl-tRNA synthetase alpha chain PheS SWALL:SYFA_BACSU (SWALL:P17921) (344 aa) fasta scores: E(): 2.6e-54, 44.02% id in 343 aa, and to Escherichia coli phenylalanyl-tRNA synthetase alpha chain PheS or B1714 SWALL:SYFA_ECOLI (SWALL:P08312) (327 aa) fasta scores: E(): 7.1e-52, 44.71% id in 331 aa; Belongs to the class-II aminoacyl-tRNA synthetase fa [...]
  
    0.652
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
 
 0.649
rplO
50s ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
 
 
   0.590
rplT
50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
 
   0.585
rplX
50S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
 
   0.563
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
  
    0.521
rplQ
Similar to Mycobacterium leprae 50S ribosomal protein L17 RplQ or ML1956 or MLCB1222.26c SW:RL17_MYCLE (Q9X797) (170 aa) fasta scores: E(): 3.1e-26, 58.86% id in 158 aa.
  
   0.518
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
   
   0.505
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.499
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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